The unexpected “butterfly effect” of Pt-coordinated cyanine self-assembly for enhanced tumor photothermal therapy

IF 6.8 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Science China Materials Pub Date : 2024-07-18 DOI:10.1007/s40843-024-2976-8

Erting Feng (, ), Fangyuan Lv (, ), Shanliang Tang (, ), Jianjun Du (, ), Shibo Lv (, ), Yingnan Wu (, ), Dapeng Liu (, ), Panwang Zhou (, ), Fengling Song (, ), Xiaojun Peng (, )

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Abstract

J-aggregates of cyanine have shown great merits in tumor photothermal therapy (PTT) due to their distinct redshift absorption as well as superior photothermal conversion efficiency (PCE). However, due to the complexity of intermolecular interactions, especially the impact of steric hindrance on aggregation, exploring effective strategies to regulate the aggregation modes of organic materials remains challenging. Herein, steric hindrance-regulated J-aggregation of near-infrared (NIR) cyanine was reported based on Pt-coordinated cyanine self-assembly with unexpected “butterfly effect”. Two Pt-coordinated cyanine dimers CyR-Pt (R = Me and Et) were synthesized and spontaneously self-assembled into aggregates in aqueous solution. CyEt-Pt aggregates were loose and amorphous stacking. By replacing ethyl with methyl to reduce steric hindrance, a tiny change resulted in the generation of tightly stacked cyanine J-aggregates (thickness less than 3 nm) observed in CyMe-Pt self-assembly. Significantly, this unexpected “butterfly effect” enabled CyMe-Pt J-aggregates to effectively inhibit reactive oxygen species and greatly improve its photostability. Besides, CyMe-Pt J-aggregates with NIR-II absorption exhibited outstanding photothermal stability and higher PCE (η = 37%) than CyEt-Pt disordered aggregates (η = 20%). Evident tumor suppression performance of CyMe-Pt J-aggregates was validated under 980 nm laser irradiation, demonstrating its great potential in tumor PTT.

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铂配位氰基自组装的意外 "蝴蝶效应 "促进肿瘤光热治疗

氰的 J-聚集体因其独特的红移吸收和卓越的光热转换效率（PCE）而在肿瘤光热疗法（PTT）中大显身手。然而，由于分子间相互作用的复杂性，特别是立体阻碍对聚集的影响，探索调节有机材料聚集模式的有效策略仍具有挑战性。本文报道了基于铂配位氰基自组装的立体阻碍调控的近红外（NIR）氰基的J-聚集，具有意想不到的 "蝴蝶效应"。研究人员合成了两种铂配位氰基二聚体 CyR-Pt（R = Me 和 Et），并在水溶液中自发地自组装成聚合体。CyEt-Pt 聚集体呈松散的无定形堆积。通过用甲基取代乙基以减少立体阻碍，一个微小的变化就产生了在 CyMe-Pt 自组装中观察到的紧密堆积的氰基 J-聚集体（厚度小于 3 纳米）。值得注意的是，这种意想不到的 "蝴蝶效应 "使 CyMe-Pt J 聚体能够有效抑制活性氧，大大提高了其光稳定性。此外，与 CyEt-Pt 无序聚集体（η = 20%）相比，具有近红外-II 吸收能力的 CyMe-Pt J-聚集体具有出色的光热稳定性和更高的 PCE（η = 37%）。在980纳米激光照射下，CyMe-Pt J-聚集体明显的肿瘤抑制性能得到了验证，显示了其在肿瘤PTT方面的巨大潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science China Materials Materials Science-General Materials Science

CiteScore

11.40

自引率

7.40%

发文量

949

期刊介绍： Science China Materials (SCM) is a globally peer-reviewed journal that covers all facets of materials science. It is supervised by the Chinese Academy of Sciences and co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. The journal is jointly published monthly in both printed and electronic forms by Science China Press and Springer. The aim of SCM is to encourage communication of high-quality, innovative research results at the cutting-edge interface of materials science with chemistry, physics, biology, and engineering. It focuses on breakthroughs from around the world and aims to become a world-leading academic journal for materials science.