Ethical concerns in aging research: perspectives of global frontline researchers.

IF 8 2区生物学 Q1 BIOLOGY

Science China Life Sciences Pub Date : 2024-10-01 Epub Date: 2024-07-19 DOI:10.1007/s11427-024-2650-y

Yaojin Peng, Lulu Ding, Zhenyu Xiao, Moshi Song, Jianwei Lv, Guang-Hui Liu

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引用次数: 0

Abstract

This study investigated the ethical landscape of aging research amid the increasing global focus on extending the human lifespan and health span. Our global survey of 180 researchers across 38 jurisdictions revealed divergent perceptions of aging, a consensus regarding the feasibility of delaying aging, and multiple perspectives regarding lifespan extension. The present findings underscore a paradigm shift toward inclusive and ethically sound research, emphasizing the need for an approach that strikes a balance between basic and clinical research. In addition, this study highlighted key ethical concerns in aging research, including the effects of misleading advertising, potential inequality in access to aging interventions, and risks pertaining to the extrapolation of research findings from lower-model organisms to humans. The insights presented in this paper call for an integrated approach for overcoming the complex ethical and societal challenges in aging research to ensure responsible and equitable advancements in this burgeoning field.

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老龄化研究中的伦理问题：全球一线研究人员的观点。

在全球日益关注延长人类寿命和健康期限的背景下，本研究调查了老龄化研究的伦理状况。我们对全球 38 个辖区的 180 名研究人员进行了调查，发现他们对衰老的看法各不相同，但对延缓衰老的可行性达成了共识，并对延长寿命持有多种观点。本研究结果强调了向包容性和伦理性研究的范式转变，强调了在基础研究和临床研究之间取得平衡的必要性。此外，本研究还强调了老龄化研究中的主要伦理问题，包括误导性广告的影响、在获得老龄化干预措施方面可能存在的不平等，以及将低等模型生物的研究结果外推至人类的相关风险。本文提出的见解呼吁采用综合方法来克服老龄化研究中复杂的伦理和社会挑战，以确保在这一新兴领域取得负责任和公平的进步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science China Life Sciences BIOLOGY-

CiteScore

15.10

自引率

8.80%

发文量

2907

审稿时长

3.2 months

期刊介绍： Science China Life Sciences is a scholarly journal co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China, and it is published by Science China Press. The journal is dedicated to publishing high-quality, original research findings in both basic and applied life science research.