Evidence for the Hepato-Retinal Axis: A Systematic Review.

IF 0.9 4区医学 Q4 OPHTHALMOLOGY

Ophthalmic surgery, lasers & imaging retina Pub Date : 2024-10-01 Epub Date: 2024-07-01 DOI:10.3928/23258160-20240524-01

Blanche L Kuo, Justin C Muste, Matthew W Russell, Anna K Wu, Carolina C S Valentim, Rishi P Singh

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引用次数: 0

Abstract

Background and objective: Liver health has been reported to be associated with retinal pathology in various ways. These include deposition of retino-toxins, neovascular drive, and disruption of the blood-retina barrier. Extrahepatic synthesis of implicated molecules and hemodynamic changes in liver dysfunction are also considered. The objective was to review the current evidence for and against a hepato-retinal axis that may guide further areas of preclinical and clinical investigation.

Methods: This was a systematic review. PubMed and Cochrane were queried for English language studies examining the connection between hepatic dysfunction and retinal pathology.

Results: Fourteen studies were included and examined out of 604 candidate publications. The studies selected include preclinical studies as well as clinical case series and studies.

Conclusions: Several liver pathologies may be linked to retinal pathology as mediated by hepatically synthesized molecules. The hepato-retinal axis may be present and further, targeted studies of the axis are warranted. [Ophthalmic Surg Lasers Imaging Retina 2024;55:587-596.].

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肝肾轴的证据：系统回顾。

背景和目的：据报道，肝脏健康与视网膜病变有多种关联。其中包括视网膜毒素的沉积、新生血管的驱动以及血液-视网膜屏障的破坏。此外，还考虑了相关分子的肝外合成和肝功能异常时的血液动力学变化。目的是回顾目前支持和反对肝-视网膜轴的证据，以指导临床前和临床研究的进一步领域：这是一项系统性综述。方法：这是一项系统性综述，在 PubMed 和 Cochrane 上查询了研究肝功能障碍与视网膜病理学之间联系的英文研究：结果：在 604 篇候选出版物中，有 14 项研究被纳入并进行了审查。所选研究包括临床前研究以及临床病例系列和研究：结论：通过肝脏合成的分子介导，一些肝脏病变可能与视网膜病变有关。肝-视网膜轴可能存在，有必要对该轴进行进一步的针对性研究。[眼科手术激光成像视网膜2024;55:XX-XX]。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic surgery, lasers & imaging retina OPHTHALMOLOGY-SURGERY

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.