Online identification of chemical constituents in Mongolian medicine Zhachong-13 pills by UHPLC-Q-exactive Orbitrap MS

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-01-02 DOI:10.1080/10286020.2024.2379981

Cai-Yun Tian , Qing-Rui Yang , Ling-Xuan Fan , Yu-Mei Yang , Bo-Wen Gao , Jian-Bo Yang

引用次数: 0

Abstract

Zhachong-13 pills (ZC-13), as a traditional prescription of Mongolian medicine, are often used in the clinical practice of Mongolian hospitals for the treatment of stroke and rheumatic arthritis. In this experiment, UHPLC-Q-Exactive Orbitrap MS was used to explore the chemical composition of ZC-13. The results showed that 315 compounds were identified or inferred, including 56 alkaloids, 77 2-(2-phenylethyl)chromones, 61 flavonoids, 31 tannins, 8 coumarins, 16 lignans, 21 terpenoids, 5 amino acids, 19 organic acids, and 21 other components. In addition, the pharmacological activities related to anti-cerebral ischemia of these components were summarized. This result laid a foundation for further study on the pharmacodynamic material basis of ZC-13 and provided a scientific basis for the formulation of ZC-13 quality specifications.

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超高效液相色谱-Q-反应式 Orbitrap MS 在线鉴定蒙药扎冲十三味丸中的化学成分

扎冲十三味丸（ZC-13）是蒙医药的传统处方，在蒙医医院临床上经常用于治疗中风和风湿性关节炎。本实验采用超高效液相色谱-Q-Exactive Orbitrap MS对ZC-13的化学成分进行了研究。结果表明，共鉴定或推断出 315 种化合物，其中包括 56 种生物碱、77 种 2-（2-苯基乙基）色酮、61 种黄酮类、31 种鞣质、8 种香豆素、16 种木质素、21 种萜类、5 种氨基酸、19 种有机酸和 21 种其他成分。此外，还总结了这些成分在抗脑缺血方面的药理活性。这一结果为进一步研究 ZC-13 的药效物质基础奠定了基础，也为制定 ZC-13 质量标准提供了科学依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.

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4-Coumaric acid

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Caffeic acid

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Citric acid