The Effect of Adding Daily 50 mg Intramuscular Progesterone to 800 mg Progesterone Suppository on The In Vitro Fertilization Success Rate in Women with Low Progesterone Levels: A Clinical Trial Study.

IF 2.3 Q2 OBSTETRICS & GYNECOLOGY
Mahbod Ebrahimi, Firoozeh Akbari Asbagh, Fatemeh Davari Tanha, Fatemeh Amirkhanloo, Ghazal Sahraiyan, Elham Feizabad, Sara Lotfi
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引用次数: 0

Abstract

Background: A low progesterone level on the embryo transfer (ET) day significantly reduces the pregnancy rate. Therefore, the present study aims to investigate the effect of adding daily 50 mg intramuscular progesterone to a total of 800 mg progesterone suppository on the in vitro fertilization (IVF) success rate in women with low progesterone levels.

Materials and methods: This parallel open-label clinical trial was performed on 218 IVF candidate infertile women who had <9.2 ng/ml progesterone levels on the ET day. These women were randomised to the intervention or control group using the randomisation allocation rule. In the intervention group, 50 mg progesterone was prescribed intramuscularly once daily in addition to 400 mg of progesterone suppository every 12 hours from the day of ET. The control group received only 400 mg of progesterone suppositories every 12 hours. In the case of pregnancy, the drugs above were continued until 12 weeks after the ET.

Results: Clinical pregnancy occurred in 54 (50.0%) women in the intervention group and in 39 (36.8%) women in the control group, which was significantly different (P=0.035). Ongoing pregnancy occurred in 47 (43.5%) women in the intervention group, and 33 (31.1%) women in the control group, which was significantly different (P=0.042). There were no significant differences in terms of abortion and multiple pregnancy rates between the two groups.

Conclusion: Intramuscular injection of 50 mg progesterone significantly increases the clinical and ongoing pregnancy rates (registration number: IRCT20150105020558N6).

在 800 毫克黄体酮栓剂中添加每日 50 毫克肌肉注射黄体酮对低黄体酮水平妇女体外受精成功率的影响:临床试验研究。
背景:胚胎移植(ET)日孕酮水平低会显著降低妊娠率。因此,本研究旨在探讨在总共 800 毫克黄体酮栓剂的基础上,每天增加 50 毫克肌肉注射黄体酮对低黄体酮水平妇女体外受精(IVF)成功率的影响:这项平行开放标签临床试验是针对 218 名体外受精候选不孕妇女进行的:干预组有 54 名(50.0%)妇女临床妊娠,对照组有 39 名(36.8%)妇女临床妊娠,两组差异显著(P=0.035)。干预组有 47 名(43.5%)妇女持续妊娠,对照组有 33 名(31.1%)妇女持续妊娠,两组差异显著(P=0.042)。两组在流产率和多胎妊娠率方面无明显差异:肌肉注射 50 毫克黄体酮可显著提高临床妊娠率和持续妊娠率(注册号:IRCT20150105020558N6)。
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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
68
审稿时长
>12 weeks
期刊介绍: International Journal of Fertility & Sterility is a quarterly English publication of Royan Institute . The aim of the journal is to disseminate information through publishing the most recent scientific research studies on Fertility and Sterility and other related topics. Int J Fertil Steril has been certified by Ministry of Culture and Islamic Guidance in 2007 and was accredited as a scientific and research journal by HBI (Health and Biomedical Information) Journal Accreditation Commission in 2008. Int J Fertil Steril is an Open Access journal.
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