Live Birth after Cleavage-Stage versus Blastocyst-Stage Embryo Transfer in Assisted Reproductive Technology: A Randomised Controlled Study.

IF 2.3 Q2 OBSTETRICS & GYNECOLOGY
Malihe Mahmoudinia, Behnaze Sovizi, Seyed Mohammad Reza Ebadi, Faezeh Zakerinasab, Tahereh Sadeghi, Mahbbobeh Mahmoudinia
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引用次数: 0

Abstract

Background: Blastocyst stage transfer appears to improve pregnancy outcomes. The aim of this study is to evaluate the pregnancy results between fresh cycle blastocyst stage embryo transfer and cleavage stage embryo transfer in patients who undergo intracytoplasmic sperm injection (ICSI).

Materials and methods: This randomised clinical trial study was conducted at the Infertility Research Centre of Milad Hospital in Mashhad, Iran from 2018 to 2020 on 240 infertile women who presented for their first ICSI procedure. These patients were assigned to receive either cleavage embryo transfer (n=112) or blastocyst stage transfer (n=107). Pregnancy outcomes were measured in both groups.

Results: There were no differences regarding age, body mass index (BMI), serum follicle-stimulating hormone (FSH), duration of infertility, and aetiology of infertility between the groups (P>0.05). There were more follicles, total oocytes, and metaphase II (M2) oocytes in the blastocyst stage group. Considerably more cleavage stage embryos were transferred compared to the number of transferred blastocysts (P=0.001). The blastocyst group had more vitrified embryos than the cleavage group (P=0.000). The rates of implantation (P=0.332), chemical pregnancy (P=0.165), clinical pregnancy (P=0.694), and live births (P=0.727) were higher in the blastocyst group, but they were not significantly different. The rate of abortion was also not significantly higher in the blastocyst group (P=0.296).

Conclusion: Blastocysts transferred in the fresh cycle of an ICSI procedure may be more advantageous compared to cleavage stage embryo transfer (registration number: IRCT20181030041503N1).

辅助生殖技术中卵裂期胚胎移植与囊胚期胚胎移植后的活产:随机对照研究
背景:囊胚期胚胎移植似乎可改善妊娠结局。本研究旨在评估卵胞浆内单精子显微注射(ICSI)患者新鲜周期囊胚期胚胎移植与卵裂期胚胎移植的妊娠结果:这项随机临床试验研究于2018年至2020年在伊朗马什哈德的米拉德医院不孕不育研究中心进行,对象是240名首次接受卵胞浆内单精子显微注射(ICSI)的不孕妇女。这些患者被分配接受裂解期胚胎移植(112 人)或囊胚期胚胎移植(107 人)。对两组患者的妊娠结果进行了测量:结果:两组患者在年龄、体重指数(BMI)、血清促卵泡激素(FSH)、不孕时间和不孕病因方面均无差异(P>0.05)。囊胚期组的卵泡、卵母细胞总数和移行期 II(M2)卵母细胞数均多于囊胚期组。与移植的囊胚数量相比,移植的卵裂期胚胎数量要多得多(P=0.001)。囊胚组玻璃化胚胎数量多于卵裂组(P=0.000)。囊胚组的着床率(P=0.332)、化学妊娠率(P=0.165)、临床妊娠率(P=0.694)和活产率(P=0.727)均高于囊胚组,但差异不显著。囊胚组的流产率也没有明显增加(P=0.296):结论:与卵裂期胚胎移植(注册号:IRCT20181030041503N1)相比,在ICSI手术的新鲜周期移植囊胚可能更具优势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
68
审稿时长
>12 weeks
期刊介绍: International Journal of Fertility & Sterility is a quarterly English publication of Royan Institute . The aim of the journal is to disseminate information through publishing the most recent scientific research studies on Fertility and Sterility and other related topics. Int J Fertil Steril has been certified by Ministry of Culture and Islamic Guidance in 2007 and was accredited as a scientific and research journal by HBI (Health and Biomedical Information) Journal Accreditation Commission in 2008. Int J Fertil Steril is an Open Access journal.
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