Association between organophosphorus pesticides and obesity among American adults.

IF 5.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Health Pub Date : 2024-07-20 DOI:10.1186/s12940-024-01104-z

Wei Xu, Yinqiao Dong, Shiping Liu, Fan Hu, Yong Cai

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引用次数: 0

Abstract

Objective: To investigate any connections between urinary organophosphorus pesticide (OPP) metabolites and adiposity measures.

Methods: In this study, data from the National Health and Nutrition Examination Survey (NHANES) projects from 2003 to 2008, 2011 to 2012, and 2015 to 2018 were analysed. Obesity was defined as a body mass index (BMI) of 30 kg/m² or higher. Abdominal obesity was defined as a waist circumference (WC) over 102 cm for men and 88 cm for women. Four urinary OPP metabolites (dimethyl phosphate [DMP], diethyl phosphate [DEP], dimethyl phosphorothioate [DMTP], and diethyl phosphorothioate [DETP]) and adiposity measures were examined using multiple linear regression and logistic regression analyses. The correlations between a variety of urinary OPP metabolites and the prevalence of obesity were investigated using weighted quantile sum regression and quantile g-computation regression.

Results: In this analysis, a total of 9,505 adults were taken into account. There were 49.81% of male participants, and the average age was 46.00 years old. The median BMI and WC of the subjects were 27.70 kg/m² and 97.10 cm, respectively. Moreover, 35.60% of the participants were obese, and 54.42% had abdominal obesity. DMP, DMTP, and DETP were discovered to have a negative correlation with WC and BMI in the adjusted models. DMP (OR = 0.93 [95% CI: 0.89-0.98]), DEP (OR = 0.94 [95% CI: 0.90-0.99]), DMTP (OR = 0.91 [95% CI: 0.86-0.95]), and DETP (OR = 0.85 [95% CI: 0.80-0.90]) exhibited negative associations with obesity prevalence. Similar correlations between the prevalence of abdominal obesity and the urine OPP metabolites were discovered. Moreover, the mixture of urinary OPP metabolites showed negative associations with adiposity measures, with DMTP and DETP showing the most significant effects.

Conclusion: Together, higher levels of urinary OPP metabolites in the urine were linked to a decline in the prevalence of obesity.

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有机磷农药与美国成年人肥胖之间的关系。

目的研究尿液中有机磷农药（OPP）代谢物与脂肪测量之间的联系：本研究分析了 2003 年至 2008 年、2011 年至 2012 年以及 2015 年至 2018 年国家健康与营养调查（NHANES）项目的数据。肥胖的定义是体重指数（BMI）达到或超过 30 kg/m²。腹部肥胖的定义是男性腰围 (WC) 超过 102 厘米，女性腰围超过 88 厘米。通过多元线性回归和逻辑回归分析，研究了尿液中的四种 OPP 代谢物（磷酸二甲酯 [DMP]、磷酸二乙酯 [DEP]、硫代磷酸二甲酯 [DMTP] 和硫代磷酸二乙酯 [DETP]）和脂肪测量指标。使用加权量子总和回归和量子 g 计算回归分析了各种尿液 OPP 代谢物与肥胖发生率之间的相关性：在这项分析中，共研究了 9 505 名成年人。男性参与者占 49.81%，平均年龄为 46.00 岁。受试者体重指数和腹围的中位数分别为 27.70 千克/平方米和 97.10 厘米。此外，35.60%的受试者为肥胖，54.42%为腹部肥胖。在调整模型中发现，DMP、DMTP 和 DETP 与腹围和体重指数呈负相关。DMP（OR = 0.93 [95% CI：0.89-0.98]）、DEP（OR = 0.94 [95% CI：0.90-0.99]）、DMTP（OR = 0.91 [95% CI：0.86-0.95]）和 DETP（OR = 0.85 [95% CI：0.80-0.90]）与肥胖患病率呈负相关。腹部肥胖率与尿液中的 OPP 代谢物之间也存在类似的相关性。此外，尿液中的OPP代谢物混合物与脂肪率呈负相关，其中DMTP和DETP的影响最为显著：结论：尿液中OPP代谢物水平的升高与肥胖症发病率的下降密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental Health 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

10.10

自引率

1.70%

发文量

115

审稿时长

3.0 months

期刊介绍： Environmental Health publishes manuscripts on all aspects of environmental and occupational medicine and related studies in toxicology and epidemiology. Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. Environmental Health is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.