The associations between single nucleotide polymorphisms and diabetic retinopathy risk: an umbrella review.

IF 1.3 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Endocrine journal Pub Date : 2024-09-02 Epub Date: 2024-07-20 DOI:10.1507/endocrj.EJ23-0564
Shaofen Huang, Yonghui Feng, Ying Sun, Jiazi Liu, Pu Wang, Jingrong Yu, Xin Su, Shasha Han, Shiqi Huang, Haokun Huang, Shiyun Chen, Ying Xu, Fangfang Zeng
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引用次数: 0

Abstract

This umbrella review was conducted aiming to assess the association between genetic variations and the development of diabetic retinopathy (DR) by collecting and evaluating available systematic reviews and meta-analysis results. We evaluated the methodological quality using the Measurement Tool to Assess Systematic Reviews (AMSTAR) 2.0, estimated the summary effect size by using the random effects model and calculated the 95% prediction intervals (PIs). Evidence from the included meta-analyses was graded according to established criteria as follows: convincing, highly suggestive, suggestive, weak, or not significant. This umbrella review included 32 meta-analyses of 52 candidate SNPs. The 12 selected meta-analyses were rated as "high," 2 studies were rated as "moderate," 11 studies were graded as "low," and the remaining 7 studies were graded as "critically low" in terms of methodological quality. Carriers of specific genotypes and alleles of the transcription Factor 7-like 2 C/T (TCF7L2 C/T) polymorphism (rs7903146, p < 0.001) might be more susceptible to the occurrence of DR in the homozygous and recessive models, and these associations were supported by "convincing" evidence. Significant associations were also found between interleukin-6 (IL-6) -174 G/C (rs1800795; p < 0.05) or vascular endothelial growth factor (VEGF) polymorphisms (rs2010963, rs699947, rs1570360, rs2010963, rs699947, rs2146323; all p values <0.05) and DR risk, but these associations were supported by "weak" evidence. The TCF7L2 C/T variant could be identified as a definitive genetic risk factor for the development and progression of DR. Data from additional in-depth studies are needed to establish robust evidence for the associations between polymorphisms of IL-6 or VEGF and DR.

单核苷酸多态性与糖尿病视网膜病变风险的关系:综述。
本综述旨在通过收集和评估现有的系统综述和荟萃分析结果,评估遗传变异与糖尿病视网膜病变(DR)发病之间的关联。我们使用系统综述评估工具(AMSTAR)2.0 对方法学质量进行了评估,使用随机效应模型估算了汇总效应大小,并计算了 95% 预测区间(PIs)。纳入的荟萃分析中的证据按照既定标准分级如下:有说服力、高度提示性、提示性、弱或无意义。本综述共纳入了 52 个候选 SNP 的 32 项元分析。就方法学质量而言,12 项选定的荟萃分析被评为 "高",2 项研究被评为 "中",11 项研究被评为 "低",其余 7 项研究被评为 "极低"。转录因子 7-like 2 C/T(TCF7L2 C/T)多态性(rs7903146,p < 0.001)的特定基因型和等位基因携带者在同卵和隐性模型中可能更容易发生 DR,这些关联得到了 "令人信服 "的证据支持。白细胞介素-6(IL-6)-174 G/C(rs1800795;p<0.05)或血管内皮生长因子(VEGF)多态性(rs2010963、rs699947、rs1570360、rs2010963、rs699947、rs2146323;所有 p 值均<0.05)之间也存在显著关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Endocrine journal
Endocrine journal 医学-内分泌学与代谢
CiteScore
4.30
自引率
5.00%
发文量
224
审稿时长
1.5 months
期刊介绍: Endocrine Journal is an open access, peer-reviewed online journal with a long history. This journal publishes peer-reviewed research articles in multifaceted fields of basic, translational and clinical endocrinology. Endocrine Journal provides a chance to exchange your ideas, concepts and scientific observations in any area of recent endocrinology. Manuscripts may be submitted as Original Articles, Notes, Rapid Communications or Review Articles. We have a rapid reviewing and editorial decision system and pay a special attention to our quick, truly scientific and frequently-citable publication. Please go through the link for author guideline.
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