Irritable bowel syndrome: When food is a pain in the gut

IF 7.5 2区 医学 Q1 IMMUNOLOGY
Hind Hussein, Samuel Van Remoortel, Guy E. Boeckxstaens
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引用次数: 0

Abstract

Irritable bowel syndrome (IBS) is a chronic gastrointestinal condition associated with altered bowel habits and recurrent abdominal pain, often triggered by food intake. Current treatments focus on improving stool pattern, but effective treatments for pain in IBS are still lacking due to our limited understanding of pathophysiological mechanisms. Visceral hypersensitivity (VHS), or abnormal visceral pain perception, underlies abdominal pain development in IBS, and mast cell activation has been shown to play an important role in the development of VHS. Our work recently revealed that abdominal pain in response to food intake is induced by the sensitization of colonic pain-sensing neurons by histamine produced by activated mast cells following a local IgE response to food. In this review, we summarize the current knowledge on abdominal pain and VHS pathophysiology in IBS, we outline the work leading to the discovery of the role of histamine in abdominal pain, and we introduce antihistamines as a novel treatment option to manage chronic abdominal pain in patients with IBS.

肠易激综合征:当食物让肠道感到疼痛时。
肠易激综合征(IBS)是一种慢性胃肠道疾病,与排便习惯改变和反复腹痛有关,通常由食物摄入引发。目前的治疗方法主要是改善排便模式,但由于我们对病理生理机制的了解有限,因此仍然缺乏针对肠易激综合征疼痛的有效治疗方法。内脏超敏反应(VHS)或内脏痛觉异常是肠易激综合征腹痛发生的基础,而肥大细胞活化已被证明在 VHS 的发生中扮演了重要角色。我们最近的研究发现,食物摄入引起的腹痛是由于对食物产生局部 IgE 反应后,活化的肥大细胞产生的组胺使结肠痛觉神经元敏化而诱发的。在这篇综述中,我们总结了目前有关肠易激综合征腹痛和VHS病理生理学的知识,概述了导致发现组胺在腹痛中的作用的工作,并介绍了抗组胺药作为一种新的治疗选择来控制肠易激综合征患者的慢性腹痛。
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来源期刊
Immunological Reviews
Immunological Reviews 医学-免疫学
CiteScore
16.20
自引率
1.10%
发文量
118
审稿时长
4-8 weeks
期刊介绍: Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system. The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.
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