Genetic Polymorphisms in Cardiovascular Disease: Effects Across Three Generations Exposed to Radiation from the Semipalatinsk Nuclear Test Site.

IF 3.4 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiovascular Toxicology Pub Date : 2024-09-01 Epub Date: 2024-07-19 DOI:10.1007/s12012-024-09885-y
Geir Bjørklund, Lyudmila Pivina, Yuliya Semenova
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Abstract

The population in the areas neighboring the Semipalatinsk Nuclear Test Site (SNTS) in the eastern region of Kazakhstan faces increased cardiovascular disease (CVD) risk. Previous research has not explored gene polymorphisms related to CVD in this population. Therefore, the present study examines the prevalence of six CVD-associated genotypes in three generations exposed to SNTS radiation. The genotyping of ApoE Leu28 → Pro, AGT Met174 → Thr, AGT Met235 → Thr, eNOS T786 → C, PON1 Gln192 → Arg, and EDN 1 Lys198 → Asn was performed using real-time polymerase chain reaction. The present study encompassed a cohort of 218 participants with a familial history of arterial hypertension and/or carotid artery disease spanning at least three generations. The analysis unveiled significant disparities in the prevalence of ApoE Leu28 → Pro, eNOS T786 → C, and PON1 Gln192 → Arg genotypes across different generations. Furthermore, a substantial variation in the distribution of the eNOS T786 → C genotype was observed between individuals of Kazakh and Russian ethnicities. Nevertheless, no significant discrepancies were detected in the frequencies of the investigated genotypes between genders. Further research in this area is warranted to enhance the understanding of the genetic factors contributing to CVD in the population exposed to radiation from the SNTS. Specifically, future studies should broaden the scope of genetic polymorphisms investigated and include representatives of healthy individuals who have not been exposed to radiation as controls.

心血管疾病的基因多态性:暴露于塞米巴拉金斯克核试验场辐射的三代人的影响。
哈萨克斯坦东部塞米巴拉金斯克核试验场(SNTS)附近地区的居民面临着更高的心血管疾病(CVD)风险。以往的研究尚未探究该人群中与心血管疾病相关的基因多态性。因此,本研究调查了暴露于 SNTS 辐射的三代人中六种心血管疾病相关基因型的流行情况。研究采用实时聚合酶链式反应法对 ApoE Leu28 → Pro、AGT Met174 → Thr、AGT Met235 → Thr、eNOS T786 → C、PON1 Gln192 → Arg 和 EDN 1 Lys198 → Asn 进行了基因分型。本研究涵盖了至少三代有动脉高血压和/或颈动脉疾病家族史的 218 名参与者。分析结果显示,不同世代的载脂蛋白E Leu28 → Pro、eNOS T786 → C和PON1 Gln192 → Arg基因型的患病率存在显著差异。此外,还观察到哈萨克族和俄罗斯族个体之间的 eNOS T786 → C 基因型分布存在很大差异。不过,在所调查的基因型频率中,没有发现性别间存在明显差异。有必要在这一领域开展进一步研究,以加深对暴露于 SNTS 辐射的人群中导致心血管疾病的遗传因素的了解。具体来说,未来的研究应扩大基因多态性的调查范围,并将未受辐射的健康人作为对照。
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来源期刊
Cardiovascular Toxicology
Cardiovascular Toxicology 医学-毒理学
CiteScore
6.60
自引率
3.10%
发文量
61
审稿时长
>12 weeks
期刊介绍: Cardiovascular Toxicology is the only journal dedicated to publishing contemporary issues, timely reviews, and experimental and clinical data on toxicological aspects of cardiovascular disease. CT publishes papers that will elucidate the effects, molecular mechanisms, and signaling pathways of environmental toxicants on the cardiovascular system. Also covered are the detrimental effects of new cardiovascular drugs, and cardiovascular effects of non-cardiovascular drugs, anti-cancer chemotherapy, and gene therapy. In addition, Cardiovascular Toxicology reports safety and toxicological data on new cardiovascular and non-cardiovascular drugs.
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