Perilymphatic regulatory T cell-dendritic cell interactions represent a novel axis of immunosuppression in cancer
IF 48.8
1区 医学
Q1 CELL BIOLOGY
引用次数: 0
Abstract
Dendritic cells are critical inducers of adaptive anti-tumor immunity. However, their maturation, activation, and migration are often compromised in the tumor microenvironment. In this issue, You et al. demonstrate a novel axis of suppression of dendritic cell function mediated by interaction with regulatory T cells in perilymphatic niches.
淋巴周围调节性 T 细胞-树突状细胞相互作用是癌症免疫抑制的新轴心
树突状细胞是适应性抗肿瘤免疫的关键诱导因子。然而，在肿瘤微环境中，树突状细胞的成熟、活化和迁移往往受到损害。在本期杂志中，You 等人展示了树突状细胞功能的一种新的抑制轴，它是通过与淋巴周围龛中的调节性 T 细胞相互作用而介导的。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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来源期刊
Cancer Cell
医学-肿瘤学
CiteScore
55.20
自引率
1.20%
发文量
179
审稿时长
4-8 weeks
期刊介绍：
Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows:
Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers.
Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice.
Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers.
Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies.
Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.
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