Stem Cells in Bone Tissue Engineering: Progress, Promises and Challenges.

IF 4.5 3区医学 Q2 CELL & TISSUE ENGINEERING

Stem Cell Reviews and Reports Pub Date : 2024-10-01 Epub Date: 2024-07-19 DOI:10.1007/s12015-024-10738-y

Robin Augustine, Mert Gezek, Vasilios K Nikolopoulos, Paige Lauren Buck, Nazli Seray Bostanci, Gulden Camci-Unal

引用次数: 0

Abstract

Bone defects from accidents, congenital conditions, and age-related diseases significantly impact quality of life. Recent advancements in bone tissue engineering (TE) involve biomaterial scaffolds, patient-derived cells, and bioactive agents, enabling functional bone regeneration. Stem cells, obtained from numerous sources including umbilical cord blood, adipose tissue, bone marrow, and dental pulp, hold immense potential in bone TE. Induced pluripotent stem cells and genetically modified stem cells can also be used. Proper manipulation of physical, chemical, and biological stimulation is crucial for their proliferation, maintenance, and differentiation. Stem cells contribute to osteogenesis, osteoinduction, angiogenesis, and mineralization, essential for bone regeneration. This review provides an overview of the latest developments in stem cell-based TE for repairing and regenerating defective bones.

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干细胞在骨组织工程中的应用：干细胞在骨组织工程中的应用：进展、前景与挑战》。

意外事故、先天性疾病和老年性疾病造成的骨缺损严重影响着人们的生活质量。骨组织工程（TE）的最新进展涉及生物材料支架、患者来源细胞和生物活性剂，从而实现了功能性骨再生。干细胞来源广泛，包括脐带血、脂肪组织、骨髓和牙髓，在骨组织工程中具有巨大的潜力。此外，还可使用诱导多能干细胞和转基因干细胞。适当的物理、化学和生物刺激对干细胞的增殖、维持和分化至关重要。干细胞有助于骨生成、骨诱导、血管生成和矿化，对骨再生至关重要。本综述概述了基于干细胞的TE修复和再生缺损骨骼的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stem Cell Reviews and Reports 医学-细胞生物学

CiteScore

9.30

自引率

4.20%

发文量

审稿时长

3 months

期刊介绍： The purpose of Stem Cell Reviews and Reports is to cover contemporary and emerging areas in stem cell research and regenerative medicine. The journal will consider for publication: i) solicited or unsolicited reviews of topical areas of stem cell biology that highlight, critique and synthesize recent important findings in the field. ii) full length and short reports presenting original experimental work. iii) translational stem cell studies describing results of clinical trials using stem cells as therapeutics. iv) papers focused on diseases of stem cells. v) hypothesis and commentary articles as opinion-based pieces in which authors can propose a new theory, interpretation of a controversial area in stem cell biology, or a stem cell biology question or paradigm. These articles contain more speculation than reviews, but they should be based on solid rationale. vi) protocols as peer-reviewed procedures that provide step-by-step descriptions, outlined in sufficient detail, so that both experts and novices can apply them to their own research. vii) letters to the editor and correspondence. In order to facilitate this exchange of scientific information and exciting novel ideas, the journal has created five thematic sections, focusing on: i) the role of adult stem cells in tissue regeneration; ii) progress in research on induced pluripotent stem cells, embryonic stem cells and mechanism governing embryogenesis and tissue development; iii) the role of microenvironment and extracellular microvesicles in directing the fate of stem cells; iv) mechanisms of stem cell trafficking, stem cell mobilization and homing with special emphasis on hematopoiesis; v) the role of stem cells in aging processes and cancerogenesis.