Cellular immunotherapies and immune cell depleting therapies in inflammatory bowel diseases: the next magic bullet?

IF 23 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Gut Pub Date : 2024-12-10 DOI:10.1136/gutjnl-2024-332919
Markus Friedrich Neurath, Bruce Eric Sands, Florian Rieder
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引用次数: 0

Abstract

Despite significant advances in biologic and small molecule treatments and the emergence of combination therapies to treat inflammatory bowel diseases (IBD) a large unmet need remains to control intestinal inflammation. New approaches targeting several pathways simultaneously with a favorable safety profile and agents that trigger anti-inflammatory pathways to drive durable resolution of inflammation are needed. This article discusses novel cellular immunotherapies and immune cell depleting therapies in IBD, including CAR-T cell approaches, Tr1 and T regulatory (Treg) cells and cell depleting antibodies such as rosnilimab. These novel approaches have the potential to overcome current therapeutic limitations in the treatment of IBD.

炎症性肠病的细胞免疫疗法和免疫细胞耗竭疗法:下一个灵丹妙药?
尽管生物制剂和小分子疗法取得了重大进展,而且出现了治疗炎症性肠病(IBD)的综合疗法,但控制肠道炎症的大量需求仍未得到满足。我们需要同时针对几种通路且安全性良好的新方法,以及能触发抗炎通路以推动炎症持久缓解的药物。本文讨论了IBD的新型细胞免疫疗法和免疫细胞耗竭疗法,包括CAR-T细胞疗法、Tr1和T调节(Treg)细胞以及细胞耗竭抗体(如rosnilimab)。这些新方法有可能克服目前治疗IBD的局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Gut
Gut 医学-胃肠肝病学
CiteScore
45.70
自引率
2.40%
发文量
284
审稿时长
1.5 months
期刊介绍: Gut is a renowned international journal specializing in gastroenterology and hepatology, known for its high-quality clinical research covering the alimentary tract, liver, biliary tree, and pancreas. It offers authoritative and current coverage across all aspects of gastroenterology and hepatology, featuring articles on emerging disease mechanisms and innovative diagnostic and therapeutic approaches authored by leading experts. As the flagship journal of BMJ's gastroenterology portfolio, Gut is accompanied by two companion journals: Frontline Gastroenterology, focusing on education and practice-oriented papers, and BMJ Open Gastroenterology for open access original research.
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