Carphology

IF 2.4 Q2 CLINICAL NEUROLOGY

PRACTICAL NEUROLOGY Pub Date : 2024-08-01 DOI:10.1136/pn-2024-004291

A Fo Ben

引用次数: 0

Abstract

As if the poor lab mouse hasn’t had it hard enough, these stoic cheese stealers are now encouraged to develop murine long-COVID. Brain fog is a common symptom and interleukin-1, critical in the innate defence against the pandemic virus, is elevated in the hippocampi of people who’ve had COVID. Researchers set out to investigate the impact of vaccination on this process. They confirm that SARS-CoV-2 but not H1N1 flu induces the indicative rise of interleukin-1beta and a persistent interleukin driven loss of hippocampal neurogenesis, which was ameliorated when the mice were vaccinated against COVID. Nat Immunol . 2024 doi:10.1038/s41590-024-01868-z. Neurological pragmatists keen to super-charge the placebo value …

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似乎可怜的实验鼠还不够难受，这些坚忍不拔的奶酪偷窃者现在又被鼓励患上小鼠长COVID。脑雾是一种常见的症状，而白细胞介素-1是抵御大流行性病毒的重要先天防御因子，在患过COVID的人的海马体中会升高。研究人员开始研究接种疫苗对这一过程的影响。他们证实，SARS-CoV-2 而不是 H1N1 流感会诱导白细胞介素-1beta 的指示性升高和白细胞介素驱动的海马神经发生的持续丧失，而当小鼠接种 COVID 疫苗后，这种情况得到了改善。Nat Immunol .2024 doi:10.1038/s41590-024-01868-z.神经学实用主义者热衷于提高安慰剂的价值......

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来源期刊

PRACTICAL NEUROLOGY Medicine-Neurology (clinical)

CiteScore

3.70

自引率

3.60%

发文量

113

期刊介绍： The essential point of Practical Neurology is that it is practical in the sense of being useful for everyone who sees neurological patients and who wants to keep up to date, and safe, in managing them. In other words this is a journal for jobbing neurologists - which most of us are for at least part of our time - who plough through the tension headaches and funny turns week in and week out. Primary research literature potentially relevant to routine clinical practice is far too much for any neurologist to read, let alone understand, critically appraise and assimilate. Therefore, if research is to influence clinical practice appropriately and quickly it has to be digested and provided to neurologists in an informative and convenient way.