Design strategies, advances and future perspectives of colon-targeted delivery systems for the treatment of inflammatory bowel disease

IF 10.7 1区医学 Q1 PHARMACOLOGY & PHARMACY

Asian Journal of Pharmaceutical Sciences Pub Date : 2024-08-01 DOI:10.1016/j.ajps.2024.100943

Baoxin Zheng , Liping Wang , Yan Yi , Jun Yin , Aihua Liang

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引用次数: 0

Abstract

Inflammatory bowel diseases (IBD) significantly contribute to high mortality globally and negatively affect patients' qualifications of life. The gastrointestinal tract has unique anatomical characteristics and physiological environment limitations. Moreover, certain natural or synthetic anti-inflammatory drugs are associated with poor targeting, low drug accumulation at the lesion site, and other side effects, hindering them from exerting their therapeutic effects. Colon-targeted drug delivery systems represent attractive alternatives as novel carriers for IBD treatment. This review mainly discusses the treatment status of IBD, obstacles to drug delivery, design strategies of colon-targeted delivery systems, and perspectives on the existing complementary therapies. Moreover, based on recent reports, we summarized the therapeutic mechanism of colon-targeted drug delivery. Finally, we addressed the challenges and future directions to facilitate the exploitation of advanced nanomedicine for IBD therapy.

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治疗炎症性肠病的结肠靶向给药系统的设计策略、进展和未来展望

炎症性肠病（IBD）是导致全球高死亡率的重要原因，并对患者的生活质量造成负面影响。胃肠道具有独特的解剖特点和生理环境限制。此外，某些天然或合成抗炎药物的靶向性差、在病变部位的药物蓄积量低以及其他副作用，也阻碍了它们发挥治疗效果。结肠靶向给药系统是治疗 IBD 的新型载体，具有很强的吸引力。这篇综述主要讨论了 IBD 的治疗现状、给药障碍、结肠靶向给药系统的设计策略以及对现有辅助疗法的展望。此外，根据最新报道，我们总结了结肠靶向给药的治疗机制。最后，我们探讨了促进利用先进纳米药物治疗 IBD 的挑战和未来方向。

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来源期刊

Asian Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

18.30

自引率

2.90%

发文量

审稿时长

14 days

期刊介绍： The Asian Journal of Pharmaceutical Sciences (AJPS) serves as the official journal of the Asian Federation for Pharmaceutical Sciences (AFPS). Recognized by the Science Citation Index Expanded (SCIE), AJPS offers a platform for the reporting of advancements, production methodologies, technologies, initiatives, and the practical application of scientific knowledge in the field of pharmaceutics. The journal covers a wide range of topics including but not limited to controlled drug release systems, drug targeting, physical pharmacy, pharmacodynamics, pharmacokinetics, pharmacogenomics, biopharmaceutics, drug and prodrug design, pharmaceutical analysis, drug stability, quality control, pharmaceutical engineering, and material sciences.