Ameliorative effect of resveratrol against type 2 diabetes in rats through triggering of autophagy and inhibition of mTOR pathway.

Abstract

Background: Type 2 diabetes mellitus (T2DM), which affects millions of individuals, has become a serious health problem.The mammalian target of rapamycin (mTOR) hyperactivation is a negatively involved autophagy that may in fact aid in the loss of β -cell function.Resveratrol (RSV) is a naturally occurring phytoalexin, mostly found incereals, fruits