Exploring the virome: An integral part of human health and disease

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2024-08-01 DOI:10.1016/j.prp.2024.155466

引用次数: 0

Abstract

The human microbiome is a complex network of microorganisms that includes viruses, bacteria, and fungi. The gut virome is an essential component of the immune system, which is responsible for regulating the growth and responses of the host's immune system. The virome maintains a crucial role in the development of numerous diseases, including inflammatory bowel disease (IBD), Crohn's disease, and neurodegenerative disorders. The human virome has emerged as a promising biomarker and therapeutic target. This comprehensive review summarizes the present understanding of the virome and its implications in matters of health and disease, with a focus on the Human Microbiome Project.

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探索病毒体：人类健康与疾病的重要组成部分

人类微生物组是一个复杂的微生物网络，包括病毒、细菌和真菌。肠道病毒组是免疫系统的重要组成部分，负责调节宿主免疫系统的生长和反应。病毒体在包括炎症性肠病（IBD）、克罗恩病和神经退行性疾病在内的多种疾病的发病过程中发挥着至关重要的作用。人类病毒体已成为一种有前景的生物标志物和治疗靶标。本综述总结了目前对病毒组的认识及其对健康和疾病的影响，重点介绍了人类微生物组项目。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.