{"title":"Microglia harmonize the cerebral lymphoid system clearance in perioperative neurocognitive disorders by the ATP-AMP-ADO pathway","authors":"Yongfeng Zheng , Daoyun Lei","doi":"10.1016/j.mehy.2024.111430","DOIUrl":null,"url":null,"abstract":"<div><p>Perioperative neurocognitive disorder (PND) is a cognitive dysfunction that often occurs after surgery, particularly in elderly patients. The cerebral lymphatic system, which acts as an immune scavenger for the nervous system, may play a crucial role in the development of PND. Recent studies suggest that microglia, by sensing metabolites of ATP (adenosine triphosphate), inhibit neuronal electrical activity. This inhibition may impact the driving force of the cerebral lymphatic system and impair its scavenging function. Investigating the role of microglia in regulating the cerebral lymphatic system through the ATP-AMP (adenosine monophosphate)-ADO (adenosine) pathway could provide new insights into the pathogenesis of PND and identify novel targets and strategies for its prevention and treatment.</p></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"190 ","pages":"Article 111430"},"PeriodicalIF":2.1000,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0306987724001737/pdfft?md5=40e71220c196c7eb5d7a31d545e394b0&pid=1-s2.0-S0306987724001737-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical hypotheses","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306987724001737","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Perioperative neurocognitive disorder (PND) is a cognitive dysfunction that often occurs after surgery, particularly in elderly patients. The cerebral lymphatic system, which acts as an immune scavenger for the nervous system, may play a crucial role in the development of PND. Recent studies suggest that microglia, by sensing metabolites of ATP (adenosine triphosphate), inhibit neuronal electrical activity. This inhibition may impact the driving force of the cerebral lymphatic system and impair its scavenging function. Investigating the role of microglia in regulating the cerebral lymphatic system through the ATP-AMP (adenosine monophosphate)-ADO (adenosine) pathway could provide new insights into the pathogenesis of PND and identify novel targets and strategies for its prevention and treatment.
期刊介绍：
Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.
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