Osteoclast exosomes pre-stimulate pulmonary endothelial cells to aggravate sepsis-induced acute lung injury

IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Xu Sun , Zengding Zhou , Yao Li , Feng Guo , Lei Yi
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引用次数: 0

Abstract

Micro-vascular hyperpermeability is often induced by the extensive burns and subsequent sepsis, and the most common clinical complication is acute lung injury (ALI), which is mortal and is the focus of our attention when treating large-area burns. We found that elderly patients have increased lung vascular permeability after extensive burns and the incidence of ALI is heavier than that of young people, which may be related to multiple underlying diseases in the elderly. Interestingly, some female patients who have total ovariectomy in the past also suffered more severe pulmonary vascular endothelial injury and ALI after extensive burns. So simple osteoporosis might have direct relationship with lung microvascular barrier disruption and the development of ALI under sepsis. In the clinic work, we found that Osteoporosis might exacerbate the lung edema after extensive burns. Additionally, by establishing the mice osteoporosis model and performing LPS in vivo to induce the sepsis-associated ALI model, we found that sepsis induced more severe ALI in the osteoporosis mice. Thus, we hypothesized that osteoporosis-mediated osteoclast activation might pre-stimulated pulmonary micro-endothelium and aggravate sepsis-induced endothelial injury and ALI by osteoclast exosomes.

破骨细胞外泌体预先刺激肺内皮细胞,加重脓毒症诱发的急性肺损伤
大面积烧伤及随后的脓毒症往往会诱发微血管高通透性,临床上最常见的并发症是急性肺损伤(ALI),这是致命的,也是我们治疗大面积烧伤时关注的重点。我们发现,老年患者大面积烧伤后肺血管通透性增加,ALI的发生率高于年轻人,这可能与老年人多种基础疾病有关。有趣的是,一些过去接受过全卵巢切除术的女性患者在大面积烧伤后也会出现更严重的肺血管内皮损伤和ALI。因此,单纯性骨质疏松症可能与肺微血管屏障破坏和脓毒症下的 ALI 发生有直接关系。在临床工作中,我们发现骨质疏松症可能会加重大面积烧伤后的肺水肿。此外,通过建立小鼠骨质疏松症模型和体内 LPS 诱导败血症相关 ALI 模型,我们发现败血症在骨质疏松症小鼠中诱发了更严重的 ALI。因此,我们推测骨质疏松症介导的破骨细胞活化可能会预先刺激肺微内皮,并通过破骨细胞外泌体加重脓毒症诱导的内皮损伤和 ALI。
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来源期刊
Medical hypotheses
Medical hypotheses 医学-医学:研究与实验
CiteScore
10.60
自引率
2.10%
发文量
167
审稿时长
60 days
期刊介绍: Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.
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