Efficacy of platelet rich plasma (PRP) injection in the treatment of knee pain in patients with osteoarthritis knee.

Haroon Yousaf, Aiman Zia, Abdus Samad Khan, Maria Ahmad, Ammar Ahmad, Mohammad Iftikhar Adil
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Abstract

Objective: To assess the efficacy of intra-articular PRP injections in patients with knee osteoarthritis. Study Design: Cross Sectional. Setting: Orthopedic Department of Mardan Medical Complex. Period: 13th August to 14th December 2023. Methods: Involving 50 diagnosed osteoarthritis patients at demographic data, grades of osteoarthritis, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were recorded pre-treatment. Patients received PRP injections at three intervals, and post-treatment WOMAC scores were assessed. Statistical analysis included mean, standard deviations, and a paired t-test. Results: The study comprised 66% female patients, with a mean age of 50.08±5.82 and mean BMI of 27.16±3.53. Regarding grades of osteoarthritis, grade 1, grade 2 and grade 3 comprised of n=14(28%), 19(38%), 17(34%) respectively PRP treatment significantly reduced WOMAC scores from a pre-treatment mean of 56.62±5.70 to 27.54±4.79 (p < 0.001). Conclusion: The significant reduction in WOMAC scores post-treatment suggests that intra-articular PRP injections may serve as a valuable intervention in the short term management of knee osteoarthritis.
富血小板血浆(PRP)注射治疗膝关节骨性关节炎患者膝关节疼痛的疗效。
目的评估膝关节骨性关节炎患者关节内注射 PRP 的疗效。研究设计:横断面。研究地点马尔丹医疗中心骨科。时间:20 年 8 月 13 日至 12 月 14 日2023 年 8 月 13 日至 12 月 14 日。研究方法对 50 名确诊骨关节炎患者进行治疗,记录治疗前的人口统计学数据、骨关节炎等级以及西安大略和麦克马斯特大学骨关节炎指数(WOMAC)评分。患者每隔三次接受 PRP 注射,并评估治疗后的 WOMAC 评分。统计分析包括平均值、标准差和配对 t 检验。研究结果研究中66%的患者为女性,平均年龄(50.08±5.82)岁,平均体重指数(27.16±3.53)。骨关节炎分级方面,1级、2级和3级分别为14(28%)、19(38%)和17(34%)级,PRP治疗显著降低了WOMAC评分,从治疗前的平均值(56.62±5.70)分降至(27.54±4.79)分(P < 0.001)。结论治疗后 WOMAC 评分的明显降低表明,关节内注射 PRP 可作为膝关节骨性关节炎短期治疗的重要干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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