A review of the advances in detoxification strategies of lignocellulosic hydrolysate for bio-based succinic acid production

IF 3.4 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biocatalysis and agricultural biotechnology Pub Date : 2024-07-14 DOI:10.1016/j.bcab.2024.103323

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引用次数: 0

Abstract

Succinic acid is a valuable platform chemical that can be produced from renewable resources, such as lignocellulosic biomass (LCB). The utilization of LCB to produce succinic acid involves a pretreatment step that results in a hemicellulosic hydrolysate. This hydrolysate is enriched with sugars, but it also contains inhibitory compounds at levels that could impede the growth of microorganisms due to their toxicity and can hamper fermentation process. Hydrolysate detoxification is a critical step in the production of succinic acid from lignocellulosic biomass, aiming to remove inhibitory compounds that hinder fermentation efficiency. This review evaluates hydrolysate production from lignocellulosic biomass towards succinic acid production. A comprehensive discussion was done on detoxification methods, including adsorption techniques, evaporation, overliming, neutralization, membrane filtration, solvent extraction, enzymatic, microbial, and combined detoxification approaches. Each method's principles, effectiveness, advantages, and limitations are discussed. Furthermore, future perspectives in hydrolysate detoxification for succinic acid production are outlined, focusing on tailored detoxification protocols, novel detoxification agents and technologies, biotechnological approaches, process optimization and scale-up, technoeconomic and environmental analysis, and mathematical and computational modeling. Overall, this review highlights the importance of continued research and development in hydrolysate detoxification to advance sustainable succinic acid production from lignocellulosic biomass.

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木质纤维素水解物用于生物基琥珀酸生产的解毒策略进展综述

丁二酸是一种宝贵的平台化学品，可从木质纤维素生物质（LCB）等可再生资源中生产。利用木质纤维素生物质生产丁二酸涉及一个预处理步骤，该步骤会产生半纤维素水解物。这种水解物富含糖分，但也含有一定量的抑制性化合物，由于其毒性可能会阻碍微生物的生长，并妨碍发酵过程。水解物脱毒是利用木质纤维素生物质生产琥珀酸的关键步骤，旨在去除阻碍发酵效率的抑制性化合物。本综述评估了木质纤维素生物质水解物生产琥珀酸的情况。对解毒方法进行了全面讨论，包括吸附技术、蒸发、过升华、中和、膜过滤、溶剂萃取、酶法、微生物法和组合解毒法。讨论了每种方法的原理、有效性、优势和局限性。此外，还概述了用于琥珀酸生产的水解物解毒的未来前景，重点关注定制解毒方案、新型解毒剂和技术、生物技术方法、工艺优化和规模化、技术经济和环境分析以及数学和计算模型。总之，本综述强调了继续研究和开发水解物解毒技术以推进木质纤维素生物质琥珀酸可持续生产的重要性。

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来源期刊

Biocatalysis and agricultural biotechnology Agricultural and Biological Sciences-Agronomy and Crop Science

CiteScore

7.70

自引率

2.50%

发文量

308

审稿时长

48 days

期刊介绍： Biocatalysis and Agricultural Biotechnology is the official journal of the International Society of Biocatalysis and Agricultural Biotechnology (ISBAB). The journal publishes high quality articles especially in the science and technology of biocatalysis, bioprocesses, agricultural biotechnology, biomedical biotechnology, and, if appropriate, from other related areas of biotechnology. The journal will publish peer-reviewed basic and applied research papers, authoritative reviews, and feature articles. The scope of the journal encompasses the research, industrial, and commercial aspects of biotechnology, including the areas of: biocatalysis; bioprocesses; food and agriculture; genetic engineering; molecular biology; healthcare and pharmaceuticals; biofuels; genomics; nanotechnology; environment and biodiversity; and bioremediation.