Experience and andrological follow-up after testicular tissue cryopreservation

IF 3.7 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Reproductive biomedicine online Pub Date : 2024-07-10 DOI:10.1016/j.rbmo.2024.104374

Romane Levade , Nathalie Rives , Agnès Liard , Lucie Grynberg , Nimrod Buchbinder , Pascale Schneider , Ludovic Dumont , Christine Rondanino , Aurélie Feraille

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引用次数: 0

Abstract

Research question

What is the experience and mid- and long-term andrological health follow-up of (pre)pubertal males who have undergone testicular tissue freezing (TTF)?

Design

This single-centre longitudinal retrospective cohort study reports on the mid- and long-term andrological health follow-up of (pre)pubertal males and young adults who underwent TTF for fertility preservation between January 2007 and December 2018. Medical characteristics and questionnaire data collected more than 18 months after TTF were analysed.

Results

Thirty-six patients were revisited during a medical follow-up consultation. During follow-up after TTF, 72.7% of patients could not recollect their counselling consultation prior to TTF but 42.4% of them found information about the TTF process useful and sufficient. Parents’ or legal guardians’ feedback was more positive about the counselling consultation and the TTF process. After TTF and treatment, the majority of patients (76.9%) who provided a semen sample had non-obstructive azoospermia. Higher serum concentrations of FSH and LH and lower serum concentrations of inhibin B were associated with non-obstructive azoospermia compared with patients with oligozoospermia (P = 0.0182, P = 0.0245 and P = 0.0140 respectively). During cancer treatment, about half of pubertal patients reported sexual dysfunction, decreasing to approximately 20% after treatment. However, two patients had children using sperm donation and one patient had a child through natural pregnancy.

Conclusions

The involvement of parents or legal guardians is crucial in the decision-making process for fertility preservation in (pre)pubertal boys. Regular follow-up, including the use of questionnaires, is essential to provide guidance for fertility preservation programmes and information on fertility restoration options and to address the psychosocial aspects of fertility preservation.

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睾丸组织冷冻后的经验和医学随访

研究问题接受过睾丸组织冷冻术（TTF）的（青春期前）男性的经历和中长期生理学健康随访情况如何？设计这项单中心纵向回顾性队列研究报告了2007年1月至2018年12月期间接受过TTF生育力保存术的（青春期前）男性和年轻成年人的中长期生理学健康随访情况。研究分析了TTF术后18个月以上收集到的医疗特征和问卷调查数据。结果36名患者在医疗随访会诊期间再次接受了随访。在TTF后的随访中，72.7%的患者无法回忆起TTF前的咨询，但42.4%的患者认为有关TTF过程的信息有用且充分。父母或法定监护人对辅导咨询和 TTF 过程的反馈更为积极。经过TTF和治疗后，大多数提供精液样本的患者（76.9%）患有非梗阻性无精子症。与少精子症患者相比，非梗阻性无精子症患者的血清FSH和LH浓度较高，血清抑制素B浓度较低（分别为P = 0.0182、P = 0.0245和P = 0.0140）。在癌症治疗期间，约有一半处于青春期的患者报告出现性功能障碍，治疗后这一比例降至约 20%。结论父母或法定监护人的参与在（青春期前）男孩生育力保存的决策过程中至关重要。定期随访，包括使用调查问卷，对于提供生育力保存计划指导、生育力恢复方案信息以及解决生育力保存的社会心理问题至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive biomedicine online 医学-妇产科学

CiteScore

7.20

自引率

7.50%

发文量

391

审稿时长

50 days

期刊介绍： Reproductive BioMedicine Online covers the formation, growth and differentiation of the human embryo. It is intended to bring to public attention new research on biological and clinical research on human reproduction and the human embryo including relevant studies on animals. It is published by a group of scientists and clinicians working in these fields of study. Its audience comprises researchers, clinicians, practitioners, academics and patients. Context: The period of human embryonic growth covered is between the formation of the primordial germ cells in the fetus until mid-pregnancy. High quality research on lower animals is included if it helps to clarify the human situation. Studies progressing to birth and later are published if they have a direct bearing on events in the earlier stages of pregnancy.