{"title":"Green Formulation of Descurainia sophia Aqueous Extract Mediated Ag NPs and Determination of Its Anti-Hemangioma Effects","authors":"Jiaqing Luo, Shuaishuai Mao, Aoyun Ren, Wei Huang, Chengmin Huang","doi":"10.1166/sam.2024.4687","DOIUrl":null,"url":null,"abstract":"Hemangioma is a common cancer with severe clinical signs. Finding a new anti-hemangioma supplement or drug inside of the chemotherapeutic drug is valuable. We synthesized silver nanoparticles containing Descurainia sophia leaf for investigating the anti-hemangioma, cytotoxicity,\n and antioxidant effects. Characterization of AgNPs was performed by Field Emission Scanning Electron Microscopy (FE-SEM), UV–Visible Spectroscopy (UV-Vis), and X-Ray diffraction analysis (XRD). The plain peak in the wavelength 449 nm revealed the AgNPs synthesis. TEM and FE-SEM analyses\n showed that synthesized AgNPs were found to be 16.9 to 48.43 nm mean particle size. For investigating the antioxidant efficacy, the DPPH assay was conducted. AgNPs prevented 50% of DPPH in the dilation of 40 μg/mL. To measure the anti-hemangioma efficacy of AgNPs, MTT assay was applied\n on SK HEP-1 and HAEND cell lines. AgNPs had high anti-hemangioma efficacy on above tumor cells without any significant toxicity on HUVEC. The best finding of anti-hemangioma properties of AgNPs was seen in the case of the HAEND cell line. This study indicated significant anti-hemangioma and\n antioxidant potentials of AgNPs containing Descurainia sophia.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science of Advanced Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1166/sam.2024.4687","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Hemangioma is a common cancer with severe clinical signs. Finding a new anti-hemangioma supplement or drug inside of the chemotherapeutic drug is valuable. We synthesized silver nanoparticles containing Descurainia sophia leaf for investigating the anti-hemangioma, cytotoxicity,
and antioxidant effects. Characterization of AgNPs was performed by Field Emission Scanning Electron Microscopy (FE-SEM), UV–Visible Spectroscopy (UV-Vis), and X-Ray diffraction analysis (XRD). The plain peak in the wavelength 449 nm revealed the AgNPs synthesis. TEM and FE-SEM analyses
showed that synthesized AgNPs were found to be 16.9 to 48.43 nm mean particle size. For investigating the antioxidant efficacy, the DPPH assay was conducted. AgNPs prevented 50% of DPPH in the dilation of 40 μg/mL. To measure the anti-hemangioma efficacy of AgNPs, MTT assay was applied
on SK HEP-1 and HAEND cell lines. AgNPs had high anti-hemangioma efficacy on above tumor cells without any significant toxicity on HUVEC. The best finding of anti-hemangioma properties of AgNPs was seen in the case of the HAEND cell line. This study indicated significant anti-hemangioma and
antioxidant potentials of AgNPs containing Descurainia sophia.