Retrospective Analysis of Laryngeal Cancer Patients in a Tertiary Referral Center

IF 0.7 Q4 OTORHINOLARYNGOLOGY

Turkish Archives of Otorhinolaryngology Pub Date : 2024-07-03 DOI:10.4274/tao.2024.2023-12-2

Ali Can Sungur, Ö. Bayır, Gökhan Toptaş, Şevket Aksoy, Sevilay Karahan, Volkan Yücel, Emel Çadallı Tatar, G. Saylam, M. Korkmaz

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Abstract

locoregional-free survival (LRFS), and factors affecting recurrence were analyzed. Results: We included 573 patients with a mean age of 60.1±9.8 years. Of the 573 patients, 94.2% (540) were men, 93.7% (537) were smokers, 40.1% had at least one comorbid disease, and 69.8% (400) presented with glottic LSCC. The five-year OS, DSS, DFS, and LRFS rates for all cases were 65.7%, 79.9%, 67%, and 74.7%, respectively. In early-stage LSCC treatment, the rates of OS (p=0.008), DFS (p=0.024) and LRFS (p=0.01) were statistically significantly higher in the endolaryngeal laser surgery (ELS) group compared with the radiotherapy (RT) group. In advanced-stage LSCC treatment, total laryngectomy had statistically significantly higher five-year DFS (p=0.003) and LRFS (p=0.002) rates compared to chemoradiotherapy. Conclusion: Our study showed that ELS provided higher rates of OS, DFS, and LRFS compared to RT in the treatment of early-stage LSCC. Recurrence was significantly higher in supraglottic tumors, advanced-stage tumors, and in patients with clinical N positivity.

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分析了无局部生存期（LRFS）和影响复发的因素。结果我们共纳入了573名患者，平均年龄为（60.1±9.8）岁。573例患者中，94.2%（540例）为男性，93.7%（537例）为吸烟者，40.1%至少患有一种合并症，69.8%（400例）为声门LSCC。所有病例的五年OS、DSS、DFS和LRFS率分别为65.7%、79.9%、67%和74.7%。在早期LSCC治疗中，喉内激光手术（ELS）组的OS率（P=0.008）、DFS率（P=0.024）和LRFS率（P=0.01）与放疗（RT）组相比有显著统计学差异。在晚期LSCC治疗中，与化疗放疗相比，全喉切除术的五年DFS（p=0.003）和LRFS（p=0.002）率明显更高。结论我们的研究表明，在治疗早期LSCC时，ELS的OS、DFS和LRFS率均高于RT。声门上肿瘤、晚期肿瘤和临床 N 阳性患者的复发率明显更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Turkish Archives of Otorhinolaryngology OTORHINOLARYNGOLOGY-

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