Possibilities of Using Nootropic Drugs to Reduce Neurotoxic Reactions Caused by Anti-tuberculosis Drugs in Experimental Conditions

Q4 Medicine

Tuberculosis and Lung Diseases Pub Date : 2024-07-04 DOI:10.58838/2075-1230-2024-102-3-6-11

G. Mozhokina, A. G. Samoylova, I. A. Vasilyeva

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引用次数: 0

Abstract

The objective: to evaluate the neuroprotective activity of cytoflavin and combinations of mexidol with vitamin B6 or Magne B6 by changes in behavioral reactions in rats during in-take of a neurotoxic combination of anti-tuberculosis drugs.Subjects and Methods. Non-linear female rats divided in 4 groups were used in this study. For 14 days, all rats received a combination of Mxf+Lzd+Cs+Pto daily. Additionally, rats of Group 2 were administered cytoflavin before administration of the basic combination; Group 3 – Mexidol + vitamin B6; Group 4 - Mexidol + Magne B6. Doses of anti-tuberculosis drugs, cytoflavin, Mexidol, vitamin B6 and Magne B6 correspond to the recommended doses for humans. The manifestation of neurotoxicity was assessed by changes in behavioral reactions by Open Field Test.Results. Neurotoxicity caused by the combination Mxf+Lzd+Cs+Pto was manifested by a decrease in motor activity, exploratory activity and grooming. With cytoflavin administration, all parameters of behavioral reactions in rats improved. When using Mexidol with vitamin B6, only a slight decrease in grooming versus the baseline level was observed. There was a less qualitative decrease in neurotoxicity manifestations with administration of Mexidol in combination with Magne B6.

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在实验条件下使用促诺特普酶药物减轻抗结核药物引起的神经毒性反应的可能性

目的：通过大鼠在服用具有神经毒性的抗结核药物组合时行为反应的变化，评估细胞黄素以及甲西多尔与维生素 B6 或 Magne B6 组合的神经保护活性。本研究使用非线性雌性大鼠，分为 4 组。所有大鼠每天服用 Mxf+Lzd+Cs+Pto 组合药物 14 天。此外，第 2 组大鼠在服用基本组合前服用了细胞黄素；第 3 组--Mexidol + 维生素 B6；第 4 组--Mexidol + Magne B6。抗结核药物、细胞黄素、Mexidol、维生素 B6 和 Magne B6 的剂量与人类的建议剂量一致。神经毒性的表现通过开阔地试验的行为反应变化进行评估。Mxf+Lzd+Cs+Pto组合造成的神经毒性表现为运动活动、探索活动和梳理活动的减少。给大鼠服用细胞黄素后，其行为反应的所有参数都有所改善。在使用美西多和维生素 B6 的情况下，与基线水平相比，仅观察到大鼠的梳理能力略有下降。在同时服用美西多和镁 B6 的情况下，神经毒性表现的下降幅度较小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tuberculosis and Lung Diseases Medicine-Pulmonary and Respiratory Medicine

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： The Journal is aimed for professional development of researchers, doctors, teachers of medical universities and training institutions. The Journal focuses on the presentation of results of research, case studies, issues of differential diagnostics and treatment in the phthisiologist’s practice, national programs on tuberculosis control in the Russian Federation, WHO strategies, discussion of prevention issues to stop transmission of TB/HIVco-infection, and extrapulmonary tuberculosis.