PET/CT with 68Ga-DOTA-TATE and 68Ga-FAPI in the Diagnosis of Neuroendocrine Tumors. Clinical Cases

Abstract

Purpose: To perform a comparative analysis of diagnostic efficiency of PET/CT with 68Ga-DOTA-TATE and 68Ga-FAPI on the example of clinical cases of NEO (detection of primary tumor and extra-organ metastases).Material and methods: Two patients with pancreatic NEO underwent PET/CT studies with 68Ga-DOTA-TATE and 68Ga-FAPI before treatment. PET/CT with 68Ga-DOTA-TATE successfully visualized primary tumors in both patients; evidence of a metastatic process in the liver was obtained in one patient. PET/CT with 68Ga-FAPI showed non-optimal visualization of primary tumors, no liver metastases were detected.Conclusion: PET/CT with 68Ga-DOTA-TATE is a more effective method of radionuclide diagnostics of NEO than PET/CT with 68Ga-FAPI.