The Role of Branched-Chain Amino Acids and Eicosapentaenoic Acid in Improving Body Composition and Functional Capacity in Nasopharyngeal Carcinoma Patients with Cancer Cachexia: A Case Report

Archives of The Medicine and Case Reports Pub Date : 2024-07-04 DOI:10.37275/amcr.v5i3.596

K. BetaNovianti, Krisadelfa Sutanto, N. Ratna, Mutu Manikam

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Abstract

Introduction: Cancer cachexia is a debilitating syndrome characterized by involuntary weight loss, muscle wasting, and functional decline, negatively impacting quality of life and survival. Nutritional interventions, including branched-chain amino acids (BCAAs) and eicosapentaenoic acid (EPA), have shown promise in ameliorating cachexia. This case report illustrates the potential benefits of these nutrients in a patient with nasopharyngeal carcinoma. Case presentation: A 65-year-old female presented with severe fatigue, dysphagia, and significant weight loss (11 kg in 6 months) secondary to nasopharyngeal carcinoma (T1N3Mx, stage IV). She was diagnosed with cancer cachexia and severe malnutrition. Nutritional therapy included enteral nutrition with 1.5-2 g/kgBW/day protein, 11-12 g/day BCAAs, and 1-2 g/day EPA. Conclusion: This case report suggests that a nutritional approach combining high protein, BCAAs, and EPA may improve body composition and functional capacity in patients with cancer cachexia. Further research is warranted to confirm these findings in larger studies.

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支链氨基酸和二十碳五烯酸在改善鼻咽癌患者的身体成分和功能能力方面的作用：病例报告

简介癌症恶病质是一种使人衰弱的综合征，其特征是不自主的体重减轻、肌肉萎缩和功能衰退，对生活质量和存活率产生负面影响。营养干预措施，包括支链氨基酸（BCAAs）和二十碳五烯酸（EPA），已显示出改善恶病质的前景。本病例报告说明了这些营养素对鼻咽癌患者的潜在益处。病例介绍：一名 65 岁的女性因鼻咽癌（T1N3Mx，IV 期）而出现严重疲劳、吞咽困难和体重明显下降（6 个月内体重下降 11 公斤）。她被诊断为癌症恶病质和严重营养不良。营养治疗包括肠内营养，每天每公斤体重 1.5-2 克蛋白质、每天 11-12 克 BCAAs 和每天 1-2 克 EPA。结论本病例报告表明，结合高蛋白、BCAAs 和 EPA 的营养方法可改善癌症恶病质患者的身体组成和功能能力。有必要进行进一步研究，以便在更大规模的研究中证实这些发现。

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Archives of The Medicine and Case Reports

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