Pathogenesis and Oral-Related Factors in Post-COVID-19 Mucormycosis Patients: A Protocol for a Systematic Review of Case Reports

Guillermo Cano-Verdugo, Myriam Angélica De la Garza-Ramos, Yinli Liu, Georgina Mayela Núñez-Rocha, María Natividad Ávila-Ortiz, Karina Janett Hernández-Ruiz
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Abstract

During the COVID-19 pandemic, there was a notable increase in cases of oral mucormycosis, with some researchers linking corticosteroid treatment to immune suppression, potentially increasing susceptibility to this fungal infection. Early oral manifestations may serve as indicators for timely diagnosis. This protocol for a systematic review aims to elucidate the pathogenesis and related factors of post-COVID-19 mucormycosis through the analysis of case reports. We will conduct a comprehensive search of relevant articles, excluding review articles and case series. Bias risk will be assessed using the ROBINS-E tool, and certainty of evidence will be evaluated using the GRADE framework. A narrative synthesis of the data will be performed, focusing on sociodemographic profiles, medical and family histories, diagnostic methods, treatment approaches, and dental relevance.
COVID-19后黏液瘤病患者的发病机制和口腔相关因素:病例报告的系统性回顾方案
在 COVID-19 大流行期间,口腔粘孢子菌病病例明显增加,一些研究人员认为皮质类固醇治疗与免疫抑制有关,可能会增加对这种真菌感染的易感性。早期口腔表现可作为及时诊断的指标。本系统综述旨在通过分析病例报告,阐明 COVID-19 后粘孢子菌病的发病机制和相关因素。我们将对相关文章进行全面检索,但不包括综述性文章和系列病例。将使用 ROBINS-E 工具评估偏倚风险,并使用 GRADE 框架评估证据的确定性。我们将对数据进行叙述性综合,重点关注社会人口概况、病史和家族史、诊断方法、治疗方法和牙科相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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