Harnessing crosstalk between extracellular vesicles and viruses for disease diagnostics and therapeutics

Xinxi Zhu, Xiuhui Lin, Liang Hu, Liangxing Wang, Qingfu Zhu
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引用次数: 0

Abstract

Extracellular vesicles (EVs) are increasingly acknowledged as important mediators of intercellular communication, closely related to the occurrence and development of a variety of diseases. Numerous studies have demonstrated that EVs play a multifaceted role in the infection process of viral diseases, elucidating their ability to both facilitate viral spread and inhibit infection progression. These versatile entities not only enhance infection rates and widen the scope of viral infection through the transmission of entire viruses or viral genomes, but also trigger antiviral responses and prompt cytokine secretion near the infection site, thereby fortifying the host's defense mechanisms and safeguarding neighboring cells against infection. This complicated crosstalk between EVs and viral infections prompts a deeper exploration into their roles in potential clinical applications. In this review, we aim to encapsulate the recent advances in understanding the intricate interplay between viruses and EVs, shedding light on the mechanisms underlying this vesicle-to-virion crosstalk. Furthermore, we underscore the significance of harnessing this knowledge for diagnostic and therapeutic functions in combating viral diseases.
利用细胞外囊泡和病毒之间的串扰进行疾病诊断和治疗
人们日益认识到,细胞外囊泡(EVs)是细胞间通信的重要媒介,与多种疾病的发生和发展密切相关。大量研究表明,EVs 在病毒性疾病的感染过程中发挥着多方面的作用,阐明了它们既能促进病毒传播又能抑制感染进展的能力。这些多用途实体不仅能通过传播整个病毒或病毒基因组来提高感染率和扩大病毒感染范围,还能触发感染部位附近的抗病毒反应并促使细胞因子分泌,从而强化宿主的防御机制并保护邻近细胞免受感染。EVs 与病毒感染之间的这种复杂串扰促使人们深入探讨 EVs 在潜在临床应用中的作用。在这篇综述中,我们旨在概括了解病毒与 EVs 之间错综复杂的相互作用的最新进展,揭示囊泡与病毒之间串扰的内在机制。此外,我们还强调了利用这些知识来诊断和治疗病毒性疾病的重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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