Venous Thromboembolism: Current Insights and Future Directions

Sahar Mahani, Michael V DiCaro, Nadia Tak, Sigurd Hartnett, Tillman Cyrus, Tahir Tak
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Abstract

Venous thromboembolism (VTE) is the third most common cause of death worldwide even though incidence rates differ globally. Western nations report 1 to 2 cases per 1,000 person-years, while Eastern countries exhibit lower rates (<1 per 1,000 person-years). This comprehensive review delves into diverse VTE risk factors including gender, diabetes, obesity, smoking, genetic mutations, hormonal influences, travel, infections, trauma, and cancer. Notably, VTE incidence is highest in certain cancers (such as pancreatic, liver, and non-small-cell lung cancers) and lowest in others (such as breast, melanoma, and prostate cancers). The extensive review provides essential information about prevalent factors and explores potential molecular mechanism contributing to VTE.
静脉血栓栓塞症:当前见解与未来方向
静脉血栓栓塞症(VTE)是全球第三大常见死因,尽管全球的发病率各不相同。西方国家的发病率为每千人年 1 到 2 例,而东方国家的发病率较低(<每千人年 1 例)。本综述深入探讨了各种 VTE 风险因素,包括性别、糖尿病、肥胖、吸烟、基因突变、荷尔蒙影响、旅行、感染、创伤和癌症。值得注意的是,某些癌症(如胰腺癌、肝癌和非小细胞肺癌)的 VTE 发生率最高,而其他癌症(如乳腺癌、黑色素瘤和前列腺癌)的 VTE 发生率最低。这篇内容广泛的综述提供了有关流行因素的重要信息,并探讨了导致 VTE 的潜在分子机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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