Analysis of the Clinical Value of Immunohistochemical Testing in the Pathological Diagnosis of Breast Cancer

Proceedings of Anticancer Research Pub Date : 2024-07-10 DOI:10.26689/par.v8i4.7494

Qiushuang Ma, Jirui Sun, Haizhi Qiao, Xueli Wang, Jinku Zhang

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Abstract

Objective: To investigate the clinical value of immunohistochemistry (IHC) detection in the pathological diagnosis of breast cancer. Methods: Eighty breast cancer patients admitted to Baoding No. 1 Central Hospital from June 2022 to June 2023 were selected as study subjects. The samples were divided into a positive group (40 cases) and a negative group (40 cases) according to ER and PR test results. Immunohistochemistry was performed on all patients to compare the differences between the two groups in C-erbB-2 positive expression and axillary lymph node metastasis. Results: The positive expression rate of C-erbB-2 in the positive group (35.00%) was significantly lower than that in the negative group (80.00%), with a highly significant difference (P < 0.001). The axillary lymph node metastasis rate in the positive group (40.00%) was significantly lower than that in the negative group (75.00%), with a significant difference (P < 0.05). Conclusion: Immunohistochemical detection in breast cancer pathology enhances diagnostic accuracy, predicts prognosis, and supports personalized treatment by identifying ER, PR, and C-erbB-2. It is worth being widely adopted in clinical practice.

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免疫组化检验在乳腺癌病理诊断中的临床价值分析

目的：探讨免疫组化（IHC）检测在乳腺癌病理诊断中的临床价值：探讨免疫组化（IHC）检测在乳腺癌病理诊断中的临床价值。方法选取 2022 年 6 月至 2023 年 6 月保定市第一中心医院收治的 80 例乳腺癌患者作为研究对象。根据ER和PR检测结果将样本分为阳性组（40例）和阴性组（40例）。对所有患者进行免疫组化，比较两组患者在C-erbB-2阳性表达和腋窝淋巴结转移方面的差异。结果阳性组 C-erbB-2 阳性表达率（35.00%）明显低于阴性组（80.00%），差异有显著性（P < 0.001）。阳性组的腋窝淋巴结转移率（40.00%）明显低于阴性组（75.00%），差异有显著性（P < 0.05）。结论乳腺癌病理中的免疫组化检测可通过鉴别ER、PR和C-erbB-2提高诊断准确性、预测预后并支持个性化治疗。值得在临床实践中广泛采用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of Anticancer Research

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