Ethnomedicinal Usage, Phytochemistry and Pharmacological Potential of Solanum surattense Burm. f

Pharmaceuticals Pub Date : 2024-07-15 DOI:10.3390/ph17070948

Kamrul Hasan, Shabnam Sabiha, Nurul Islam, João F. Pinto, O. Silva

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Abstract

Solanum surattense Burm. f. is a significant member of the Solanaceae family, and the Solanum genus is renowned for its traditional medicinal uses and bioactive potential. This systematic review adheres to PRISMA methodology, analyzing scientific publications between 1753 and 2023 from B-on, Google Scholar, PubMed, Science Direct, and Web of Science, aiming to provide comprehensive and updated information on the distribution, ethnomedicinal uses, chemical constituents, and pharmacological activities of S. surattense, highlighting its potential as a source of herbal drugs. Ethnomedicinally, this species is important to treat skin diseases, piles complications, and toothache. The fruit was found to be the most used part of this plant (25%), together with the whole plant (22%) used to treat different ailments, and its decoction was found to be the most preferable mode of herbal drug preparation. A total of 338 metabolites of various chemical classes were isolated from S. surattense, including 137 (40.53%) terpenoids, 56 (16.56%) phenol derivatives, and 52 (15.38%) lipids. Mixtures of different parts of this plant in water–ethanol have shown in vitro and/or in vivo antioxidant, anti-inflammatory, antimicrobial, anti-tumoral, hepatoprotective, and larvicidal activities. Among the metabolites, 51 were identified and biologically tested, presenting antioxidant, anti-inflammatory, and antitumoral as the most reported activities. Clinical trials in humans made with the whole plant extract showed its efficacy as an anti-asthmatic agent. Mostly steroidal alkaloids and triterpenoids, such as solamargine, solanidine, solasodine, solasonine, tomatidine, xanthosaponin A–B, dioscin, lupeol, and stigmasterol are biologically the most active metabolites with high potency that reflects the new and high potential of this species as a novel source of herbal medicines. More experimental studies and a deeper understanding of this plant must be conducted to ensure its use as a source of raw materials for pharmaceutical use.

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茄科植物的药用价值、植物化学和药理潜力

茄属植物茄（Solanum surattense Burm.f.）是茄科植物茄属（Solanaceae）的重要成员，以其传统药用价值和生物活性潜力而闻名。本系统综述遵循 PRISMA 方法，分析了 B-on、Google Scholar、PubMed、Science Direct 和 Web of Science 中 1753 至 2023 年间的科学出版物，旨在提供有关茄属植物分布、民族药用、化学成分和药理活性的全面、最新信息，突出其作为草药来源的潜力。在民族药用方面，该物种是治疗皮肤病、痔疮并发症和牙痛的重要药物。研究发现，果实（25%）和全株（22%）是该植物用于治疗不同疾病的最常用部分，而煎煮则是最理想的草药制备方式。从 S. surattense 共分离出 338 种不同化学类别的代谢物，包括 137 种（40.53%）萜类化合物、56 种（16.56%）酚类衍生物和 52 种（15.38%）脂类化合物。该植物不同部分在水乙醇中的混合物显示出体外和/或体内抗氧化、抗炎、抗菌、抗肿瘤、保肝和杀幼虫剂活性。在这些代谢物中，有 51 种已被鉴定并进行了生物测试，报告最多的是抗氧化、抗炎和抗肿瘤活性。使用全草提取物进行的人体临床试验表明，它具有抗哮喘的功效。大部分甾体生物碱和三萜类化合物，如索拉马金碱、索拉尼定、索拉索定、番茄红素、黄皂素 A-B、薯蓣皂素、羽扇豆醇和豆固醇，是生物活性最强的代谢产物，具有很高的药效，反映了该物种作为一种新型草药来源的巨大潜力。必须对这种植物进行更多的实验研究和更深入的了解，以确保将其用作制药原料。

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Pharmaceuticals

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