Rifampicin resistance in pulmonary and extra pulmonary tuberculosis cases in of children

Indian Journal of Microbiology Research Pub Date : 2024-07-15 DOI:10.18231/j.ijmr.2024.016

Nidhi Pal, Kushal Singh, U. S. Tomar, A.K. Sahni

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Abstract

: The prevalence of Rifampicin-resistant MTB/EPTB in children in India is a growing concern. Globally a large proportion of childhood tuberculosis (TB) cases are diagnosed based only on clinical findings. This study was undertaken to measure MTB positivity and their rifampicin resistance rates in different clinical samples from children. : Different samples of clinically suspected tuberculosis in children were included. All the samples were tested for Tuberculosis positivity and Rifampicin (Rif) resistance by GeneXpert assay. A total of 1420 samples were received from presumptive TB patients of all age group from February 2023 to January 2024. Total 1420 samples were analyzed for this study, of which 30% were male and 70% were females. Respiratory samples and extra-pulmonary samples were 1261 (88.8%) and 159 (11.2%) respectively. Among 1420, 211(14.86%) samples were from children and among these 75 (35.55%) were found MTB positive and 7 (9.33%) were Rif resistant MTB. Of 75 MTB detected patients, 77.8% and 22.2% MTB detected in female and male children respectively. There are higher prevalence of Rif resistant MTB in children so it is important for healthcare providers in India to be vigilant in timely diagnosis, individualized treatment and enhance surveillance. It is essential to combat this growing threat and protect the health of children.

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儿童肺结核和肺外结核病例对利福平的耐药性

:印度儿童对利福平耐药的 MTB/EPTB 感染率日益令人担忧。在全球范围内，很大一部分儿童结核病（TB）病例仅根据临床结果进行诊断。本研究旨在检测不同儿童临床样本中 MTB 阳性率及其对利福平的耐药率。研究对象：临床疑似结核病儿童的不同样本。所有样本均通过 GeneXpert 检测法进行结核菌阳性和利福平（Rif）耐药性检测。从 2023 年 2 月至 2024 年 1 月，共收到 1420 份来自各年龄组推定肺结核患者的样本。本研究共分析了 1420 份样本，其中 30% 为男性，70% 为女性。呼吸道样本和肺外样本分别为 1261 份（88.8%）和 159 份（11.2%）。在 1420 份样本中，211 份（14.86%）来自儿童，其中 75 份（35.55%）发现 MTB 阳性，7 份（9.33%）是对利福耐药的 MTB。在检出 MTB 的 75 名患者中，女性和男性分别占 77.8%和 22.2%。对利福夫耐药的 MTB 在儿童中的流行率较高，因此印度的医疗保健提供者必须提高警惕，及时诊断、个性化治疗并加强监测。应对这一日益严重的威胁和保护儿童健康至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Indian Journal of Microbiology Research

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