In-vitro and in-silico evaluation of anticancer potential of Oxalis corniculata

IF 1.8 Q3 PHARMACOLOGY & PHARMACY
Meghna Ravishankar Valakatte, Vibha Viswanath, Manasa Aithal, Prashantha Karunakar, Shanti Koppala Narayanappa
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Abstract

Plant secondary metabolites have been gaining significant attention as potential cancer therapeutics in recent years. In several cases, these are present in plants that are commonly found in the surrounding environment. This study explores the anticancer properties of the methanolic extract of Oxalis corniculata, a common creeper plant known to have medicinal properties. The phytochemical characterization of the extract was performed by biochemical tests and gas chromatography mass spectrometry (GCMS). Cytotoxicity studies on the HCT-116 cell line have shown that the extract can inhibit cell proliferation with an IC50 value of 119.498 µg/mL. Through molecular docking and molecular dynamics simulation, it has been observed that two constituents of the extract namely Desulphosinigrin and d-Glycero-d-ido-heptose exhibit strong and specific interactions with the caspase binding site of the X-linked inhibitor of apoptosis protein (XIAP). Thus, these compounds may be capable of inhibiting XIAP in the cellular environment, thereby promoting apoptosis, resulting in the death of cancer cells.

Abstract Image

牛樟芝抗癌潜力的体外和体内评估
近年来,植物次生代谢物作为潜在的癌症治疗药物越来越受到人们的关注。在一些情况下,这些物质存在于周围环境中常见的植物中。本研究探讨了一种具有药用价值的常见匍匐植物 Oxalis corniculata 的甲醇提取物的抗癌特性。通过生化测试和气相色谱质谱法(GCMS)对提取物进行了植物化学鉴定。对 HCT-116 细胞系进行的细胞毒性研究表明,该提取物可抑制细胞增殖,IC50 值为 119.498 µg/mL。通过分子对接和分子动力学模拟,可以观察到提取物中的两种成分,即脱落磷苷和 d-缩水甘油-d-庚糖,与 X 连环凋亡抑制蛋白(XIAP)的 Caspase 结合位点有很强的特异性相互作用。因此,这些化合物可能能够抑制细胞环境中的 XIAP,从而促进细胞凋亡,导致癌细胞死亡。
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来源期刊
Advances in Traditional Medicine
Advances in Traditional Medicine PHARMACOLOGY & PHARMACY-
CiteScore
4.30
自引率
0.00%
发文量
50
期刊介绍: Advances in Traditional Medicine (ADTM) is an international and peer-reviewed journal and publishes a variety of articles including original researches, reviews, short communications, and case-reports. ADTM aims to bridging the gap between Traditional knowledge and medical advances. The journal focuses on publishing valid, relevant, and rigorous experimental research and clinical applications of Traditidnal Medicine as well as medical classics. At the same time, the journal is devoted to communication among basic researcher and medical clinician interested in the advancement of Traditional Medicine. Topics covered by the journal are: Medical Classics & History; Biomedical Research; Pharmacology & Toxicology of Natural Products; Acupuncture & Moxibustion; Sasang Constitutional Medicine; Diagnostics and Instrumental Development; Clinical Research. ADTM is published four times yearly. The publication date of this journal is 30th March, June, September, and December.
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