Exploring the interplay between iron metabolism imbalance and esophageal cancer

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-16 DOI:10.1515/oncologie-2024-0147

Lu Qi, Zhongwen Li

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Abstract

Iron metabolism plays a crucial role in various physiological processes, and its dysregulation has been implicated in many cancers. Epidemiological studies have confirmed a significant correlation between iron overload and an increased risk of oesophageal cancer. The purpose of this review is to investigate the relationship between iron metabolism imbalance and oesophageal cancer and to explore the potential application of iron metabolism regulatory mechanisms in the treatment of oesophageal cancer. This paper details the physiological mechanisms that regulate cellular iron homeostasis, including absorption, storage, utilization, and excretion and focuses on changes in iron homeostasis in oesophageal cancer cells. In addition, the paper discusses the multifaceted roles of iron in tumourigenesis, progression and metastasis, as well as the impact of iron metabolism in the tumour microenvironment. Finally, this paper discusses the potential impact of ferroptosis on cancer cell survival, highlights the importance of iron metabolism in oesophageal cancer, and provides new ideas for the prevention, diagnosis and treatment of oesophageal cancer. Future research should further elucidate the specific role of iron metabolism in esophageal cancer pathogenesis and explore new therapeutic approaches using these mechanisms for more effective treatment strategies.

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探索铁代谢失衡与食道癌之间的相互作用

铁代谢在各种生理过程中起着至关重要的作用，其失调与许多癌症有关。流行病学研究证实，铁超载与食道癌风险增加之间存在显著相关性。本综述旨在研究铁代谢失衡与食道癌之间的关系，并探讨铁代谢调节机制在食道癌治疗中的潜在应用。本文详细介绍了调节细胞铁平衡的生理机制，包括吸收、储存、利用和排泄，并重点探讨了食道癌细胞中铁平衡的变化。此外，本文还讨论了铁在肿瘤发生、发展和转移中的多方面作用，以及铁代谢对肿瘤微环境的影响。最后，本文讨论了铁变态反应对癌细胞存活的潜在影响，强调了铁代谢在食道癌中的重要性，并为食道癌的预防、诊断和治疗提供了新思路。未来的研究应进一步阐明铁代谢在食管癌发病机制中的具体作用，并探索利用这些机制的新治疗方法，以制定更有效的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.