{"title":"Visible light induced selective cleavage of single C(sp3)-F bond in trifluoromethyl groups containing compounds","authors":"","doi":"10.1016/j.tet.2024.134155","DOIUrl":null,"url":null,"abstract":"<div><p>Molecules bearing a difluoromethyl motif have found widely utility in the pharmaceutical, agrochemical and material sciences. Visible light induced selective cleavage of single C(sp<sup>3</sup>)-F bond in trifluoromethyl groups is one of the promising routes to obtain <em>gem</em>-difluoromethyl unit, and it had made great achievements in this filed. This article aims at highlighting works on the methods in visible light induced selective cleavage of single C(sp<sup>3</sup>)-F bond in trifluoromethyl(hetero)arenes, trifluoromethylalkenes and trifluoromethyl bearing on α-carbonyl carbon, paying particular attention to the most recent advances (year >2016). It will provide a guide for fostering new ideas, and thus stimulates more innovations.</p></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040402024003351","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Molecules bearing a difluoromethyl motif have found widely utility in the pharmaceutical, agrochemical and material sciences. Visible light induced selective cleavage of single C(sp3)-F bond in trifluoromethyl groups is one of the promising routes to obtain gem-difluoromethyl unit, and it had made great achievements in this filed. This article aims at highlighting works on the methods in visible light induced selective cleavage of single C(sp3)-F bond in trifluoromethyl(hetero)arenes, trifluoromethylalkenes and trifluoromethyl bearing on α-carbonyl carbon, paying particular attention to the most recent advances (year >2016). It will provide a guide for fostering new ideas, and thus stimulates more innovations.
期刊介绍:
Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry.
Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters.
Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.