Environmental implications of dental restorative materials on the zebrafish Danio rerio: Are dental chair drainage systems an emerging environmental threat?

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2024-07-15 DOI:10.1016/j.etap.2024.104499

Matea Majstorović , Sanja Babić Brčić , Olga Malev , Matej Par , Igor Živković , Marijan Marciuš , Zrinka Tarle , Rozelindra Čož-Rakovac , Danijela Marović

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引用次数: 0

Abstract

This study aimed to evaluate the environmental impact of dental materials: commercial composite Tetric EvoCeram®, glass ionomer Equia Forte® HT Fil, laboratory-prepared composite, alkasite Cention® Forte, amalgam Amalcap® Plus, and samples from dental chair drainage systems (DCDS). Methacrylate monomers were detected in the eluates of experimental and commercials composites, and alkasite. In DCDS samples solely mercury was found at concentrations of 0.08–1.86 μg/L. The experimental composite (48 h incubation) exhibited the highest toxicity on zebrafish Danio rerio (LC₅₀=0.70 g/L), followed by amalgam (LC₅₀=8.27 g/L) < Tetric EvoCeram® (LC₅₀=10.94 g/L) < Equia Forte® HT Fil (LC₅₀=24.84 g/L) < Cention® Forte (LC₅₀=32.22 g/L). Exposure of zebrafish to DCDS samples resulted in decreased larval body length and increased occurrences of edema and blood accumulation. The results obtained highlight the need for additional monitoring and further research on the release of unreacted monomers and mercury from dental materials and their environmental impact.

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牙科修复材料对斑马鱼的环境影响：牙椅排水系统是一种新出现的环境威胁吗？

本研究旨在评估牙科材料对环境的影响：商用复合材料 Tetric EvoCeram®、玻璃离聚体 Equia Forte® HT Fil、实验室制备的复合材料、烷基石 Cention® Forte、汞合金 Amalcap® Plus 以及牙科治疗椅排水系统 (DCDS) 的样本。在实验用复合材料、商用复合材料和烷基石的洗脱液中都检测到了甲基丙烯酸酯单体。在 DCDS 样品中，只发现了浓度为 0.08-1.86μg/L 的汞。实验性复合材料（48 小时培养）对斑马鱼 Danio rerio 的毒性最高（LC50=0.70g/L），其次是汞合金（LC50=8.27g/L）< Tetric EvoCeram®（LC50=10.94g/L）< Equia Forte® HT Fil（LC50=24.84g/L）< Cention® Forte（LC50=32.22g/L）。斑马鱼接触 DCDS 样品后，幼虫体长缩短，水肿和积血现象增加。所得结果突出表明，有必要对牙科材料中未反应单体和汞的释放及其对环境的影响进行额外监测和进一步研究。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.