Metallic nanomaterials - targeted drug delivery approaches for improved bioavailability, reduced side toxicity, and enhanced patient outcomes.

IF 1.2 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
George Alexandru Croitoru, Diana Cristina Pîrvulescu, Adelina Gabriela Niculescu, Alexandru Mihai Grumezescu, Alexandru Mihai Antohi, Carmen Larisa Nicolae
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引用次数: 0

Abstract

This paper explores the integral role of metallic nanomaterials in drug delivery, specifically focusing on their unique characteristics and applications. Exhibiting unique size, shape, and surface features, metallic nanoparticles (MNPs) (e.g., gold, iron oxide, and silver NPs) present possibilities for improving medication efficacy while minimizing side effects. Their demonstrated success in improving drug solubility, bioavailability, and targeted release makes them promising carriers for treating a variety of diseases, including inflammation and cancer, which has one of the highest rates of mortality in the world. Furthermore, it is crucial to acknowledge some limitations of MNPs in drug delivery before successfully incorporating them into standard medical procedures. Thus, challenges such as potential toxicity, issues related to long-term safety, and the need for standardized production methods will also be addressed.

金属纳米材料--提高生物利用率、减少副作用和改善患者疗效的靶向给药方法。
本文探讨了金属纳米材料在给药过程中不可或缺的作用,特别是其独特的特性和应用。金属纳米颗粒(MNPs)(如金、氧化铁和银 NPs)具有独特的尺寸、形状和表面特征,可提高药物疗效,同时最大限度地减少副作用。它们在提高药物溶解度、生物利用度和靶向释放方面的成功应用,使它们成为治疗各种疾病的理想载体,包括炎症和癌症,而癌症是世界上死亡率最高的疾病之一。此外,在成功将 MNPs 纳入标准医疗程序之前,必须认识到 MNPs 在给药方面的一些局限性。因此,还将讨论潜在毒性、与长期安全性有关的问题以及标准化生产方法的必要性等挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.70
自引率
20.00%
发文量
221
审稿时长
3-8 weeks
期刊介绍: Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).
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