Circulating Activated Platelets in Children With Long Covid: A Case-Controlled Preliminary Observation.

IF 2.9 4区医学 Q3 IMMUNOLOGY

Pediatric Infectious Disease Journal Pub Date : 2024-07-15 DOI:10.1097/INF.0000000000004470

Danilo Buonsenso, Silvia Sorrentino, Antonietta Ferretti, Rosa Morello, Piero Valentini, Leonardo Di Gennaro, Erica De Candia

引用次数: 0

Abstract

We investigated if children with Long Covid (n=14) have activated platelets compared with healthy controls (n=14). Platelet activation and secretion markers were investigated by flow cytometry using MoAbs directed against P-selectin, CD63, and PAC-1 in quiescent platelets and in platelets stimulated with 10-µM adenosine diphosphate and 25-µM protease activated receptor 1-activating peptide. Circulating platelets of patients with Long Covid had significantly increased expression of the activation marker cytometry using MoAbs directed against P-selectin (P = 0.019).

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长 Covid 患儿的循环活化血小板：病例对照初步观察。

我们研究了与健康对照组（14 人）相比，Long Covid 患儿（14 人）的血小板是否活化。通过流式细胞术，使用针对静止血小板中的 P-选择素、CD63 和 PAC-1 的 MoAbs 以及 10-µM 二磷酸腺苷和 25-µM 蛋白酶激活受体 1-激活肽刺激的血小板，对血小板活化和分泌标志物进行了研究。使用针对P-选择素的MoAbs进行细胞测量，Long Covid患者的循环血小板的活化标志物表达明显增加（P = 0.019）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Infectious Disease Journal 医学-传染病学

CiteScore

6.30

自引率

2.80%

发文量

566

审稿时长

2-4 weeks

期刊介绍： The Pediatric Infectious Disease Journal® (PIDJ) is a complete, up-to-the-minute resource on infectious diseases in children. Through a mix of original studies, informative review articles, and unique case reports, PIDJ delivers the latest insights on combating disease in children — from state-of-the-art diagnostic techniques to the most effective drug therapies and other treatment protocols. It is a resource that can improve patient care and stimulate your personal research.

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