Use and perceptions of Cannabidiol among individuals in treatment for opioid use disorder.

IF 4 2区社会学 Q1 SUBSTANCE ABUSE

Harm Reduction Journal Pub Date : 2024-07-17 DOI:10.1186/s12954-024-01051-5

Christopher Kudrich, Rebecca Chen, Yuan Meng, Keren Bachi, Yasmin L Hurd

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引用次数: 0

Abstract

Background: Cannabidiol (CBD) is a widely available cannabis product with many claims as to potential health benefits including alleviating symptoms related to opioid use disorder (OUD). However, little is known as to how individuals with OUD perceive CBD, to what extent they may already be using CBD, and for what purposes.

Methods: A survey was conducted among individuals receiving treatment for OUD at the Addiction Institute of Mount Sinai in New York City from July 2021 to August 2023. The survey consisted of demographic questions, questions about opioid use, CBD use, and perceptions regarding CBD. Statistical analysis using ordinal logistic regression was employed to compare perceptions between CBD users and non-users while adjusting for age and race.

Results: Among 587 respondents, 550 completed the survey. Among all survey completers, 129 (23%) reported a history of using CBD for a variety of reasons including: anxiety (81, 62.8%), pain (65, 50.4%), sleep (63, 48.8%), depression (62, 48.1%), recreational purposes (32, 24.8%), or for other reasons (8, 6.2%). Of note, 22 (17.1%) respondents reported using CBD to control their addiction and 54 (41.9%) reported using CBD to ease opioid withdrawal symptoms. CBD users demonstrated more positive perceptions regarding its legality (β = 0.673, OR = 1.960, 95% CI [1.211, 3.176], p = .006), social acceptance (β = 0.718, OR = 2.051, 95% CI [1.257, 3.341], p = .004), and therapeutic potential compared to non-users. CBD users also had a more positive view of its potential future role in managing addiction (β = 0.613, OR = 1.846, 95% CI [1.181, 2.887], p = .007).

Conclusions: This study highlights a significant association between CBD usage and progressive views regarding CBD among individuals with OUD, suggesting a growing interest in CBD as a potential adjunctive therapy for individuals in substance use treatment. Some patients are already using CBD for anxiety, pain, sleep, depression, or as a harm reduction intervention to control their addiction or for opioid withdrawal symptoms. These findings underscore the importance of integrating patient perspectives into future research and treatment strategies involving CBD in the context of OUD.

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接受阿片类药物使用障碍治疗者对大麻二酚的使用和看法。

背景：大麻二酚（CBD）是一种广泛使用的大麻产品，有许多关于其潜在健康益处的说法，包括缓解与阿片类药物使用障碍（OUD）相关的症状。然而，人们对患有阿片类药物滥用症的人如何看待 CBD、他们在多大程度上使用 CBD 以及使用 CBD 的目的知之甚少：2021 年 7 月至 2023 年 8 月，在纽约市西奈山成瘾研究所对接受 OUD 治疗的患者进行了一项调查。调查内容包括人口统计学问题、阿片类药物使用问题、CBD 使用问题以及对 CBD 的看法。采用序数逻辑回归进行统计分析，比较 CBD 使用者和非使用者对 CBD 的看法，同时对年龄和种族进行调整：在 587 名受访者中，有 550 人完成了调查。在所有完成调查的受访者中，129 人（23%）称曾因各种原因使用过 CBD，包括：焦虑（81 人，62.8%）、疼痛（65 人，50.4%）、睡眠（63 人，48.8%）、抑郁（62 人，48.1%）、娱乐（32 人，24.8%）或其他原因（8 人，6.2%）。值得注意的是，22 名受访者（17.1%）称使用 CBD 来控制毒瘾，54 名受访者（41.9%）称使用 CBD 来缓解阿片类药物戒断症状。与不使用 CBD 的受访者相比，CBD 使用者对其合法性（β = 0.673，OR = 1.960，95% CI [1.211，3.176]，p = .006）、社会接受度（β = 0.718，OR = 2.051，95% CI [1.257，3.341]，p = .004）和治疗潜力有更积极的看法。CBD使用者对其未来在控制成瘾方面的潜在作用也有更积极的看法（β = 0.613，OR = 1.846，95% CI [1.181，2.887]，p = .007）：本研究强调了 CBD 的使用与 OUD 患者对 CBD 的进步观点之间的重要关联，表明人们对 CBD 作为药物使用治疗中的一种潜在辅助疗法的兴趣日益浓厚。一些患者已经在使用 CBD 治疗焦虑、疼痛、睡眠、抑郁，或将其作为一种减少伤害的干预措施来控制毒瘾或治疗阿片类药物戒断症状。这些发现强调了将患者的观点纳入未来研究和治疗策略的重要性，这些研究和治疗策略涉及在 OUD 背景下使用 CBD。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Harm Reduction Journal Medicine-Public Health, Environmental and Occupational Health

CiteScore

5.90

自引率

9.10%

发文量

126

审稿时长

26 weeks

期刊介绍： Harm Reduction Journal is an Open Access, peer-reviewed, online journal whose focus is on the prevalent patterns of psychoactive drug use, the public policies meant to control them, and the search for effective methods of reducing the adverse medical, public health, and social consequences associated with both drugs and drug policies. We define "harm reduction" as "policies and programs which aim to reduce the health, social, and economic costs of legal and illegal psychoactive drug use without necessarily reducing drug consumption". We are especially interested in studies of the evolving patterns of drug use around the world, their implications for the spread of HIV/AIDS and other blood-borne pathogens.