{"title":"Investigation of the Effect of Tai Chi Training on Depressive Symptoms in Perimenopausal Women on the Basis of Serum Kynurenine Metabolites.","authors":"Jing Liu, Jingmei Si, Weiwei Zhao","doi":"10.1080/0361073X.2024.2377427","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To observe the effects of Tai Chi training on depression symptoms and serum kynurenine metabolites in perimenopausal women and explore the mechanism of Tai Chi training in anti-depression.</p><p><strong>Methods: </strong>A total of 72 perimenopausal women with depression were randomly selected from Lishi District and divided into a Tai Chi training group (36 cases) and a control group (36 cases). At the same time, 36 perimenopausal healthy women were randomly selected as the normal group. The Tai Chi training group was intervened with 24 simplified Tai Chi exercises, and the depression self-rating scale was used to evaluate the depression status. The levels of tryptophan (Trp) and kynurenine (KYN) metabolites in serum were determined by high-performance liquid chromatography-ultraviolet detection.</p><p><strong>Results: </strong>Before the experiment, compared with the normal healthy group, the depression self-rating scale scores, serum KYN and quinolinic acid (QUIN) levels, and KYN/Trp ratio of the control group and Tai Chi group were significantly increased (<i>p</i> < .01), and the serum kynurenic acid (KYNA) level was significantly decreased (<i>p</i> < .01). After the experiment, compared with the normal healthy group, the depression self-rating scale scores of the Tai Chi group were significantly decreased (<i>p</i> < .01), the serum KYNA content was increased (<i>p</i> < .01), the serum KYN and QUIN contents were significantly decreased (<i>p</i> < .01), and the KYN/Trp ratio was significantly decreased (<i>p</i> < .01).</p><p><strong>Conclusion: </strong>Tai Chi training can significantly improve depression symptoms in perimenopausal women. The mechanism of Tai Chi training in improving depression symptoms in perimenopausal women may be achieved by regulating abnormal kynurenine metabolism.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental Aging Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/0361073X.2024.2377427","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To observe the effects of Tai Chi training on depression symptoms and serum kynurenine metabolites in perimenopausal women and explore the mechanism of Tai Chi training in anti-depression.
Methods: A total of 72 perimenopausal women with depression were randomly selected from Lishi District and divided into a Tai Chi training group (36 cases) and a control group (36 cases). At the same time, 36 perimenopausal healthy women were randomly selected as the normal group. The Tai Chi training group was intervened with 24 simplified Tai Chi exercises, and the depression self-rating scale was used to evaluate the depression status. The levels of tryptophan (Trp) and kynurenine (KYN) metabolites in serum were determined by high-performance liquid chromatography-ultraviolet detection.
Results: Before the experiment, compared with the normal healthy group, the depression self-rating scale scores, serum KYN and quinolinic acid (QUIN) levels, and KYN/Trp ratio of the control group and Tai Chi group were significantly increased (p < .01), and the serum kynurenic acid (KYNA) level was significantly decreased (p < .01). After the experiment, compared with the normal healthy group, the depression self-rating scale scores of the Tai Chi group were significantly decreased (p < .01), the serum KYNA content was increased (p < .01), the serum KYN and QUIN contents were significantly decreased (p < .01), and the KYN/Trp ratio was significantly decreased (p < .01).
Conclusion: Tai Chi training can significantly improve depression symptoms in perimenopausal women. The mechanism of Tai Chi training in improving depression symptoms in perimenopausal women may be achieved by regulating abnormal kynurenine metabolism.
目的观察太极拳训练对围绝经期妇女抑郁症状和血清犬尿氨酸代谢物的影响，探讨太极拳训练抗抑郁的机制：方法：在离石区随机选取72名围绝经期抑郁症妇女，将其分为太极拳训练组（36例）和对照组（36例）。同时，随机选取 36 名围绝经期健康妇女作为正常组。太极拳训练组接受 24 个简化太极拳练习的干预，并使用抑郁自评量表评估抑郁状况。采用高效液相色谱-紫外检测法测定血清中色氨酸（Trp）和犬尿氨酸（KYN）代谢物的含量：实验前，与正常健康组相比，对照组和太极组的抑郁自评量表评分、血清KYN和喹啉酸（QUIN）水平、KYN/Trp比值均显著升高（P P P P P P 结论：太极拳训练能显著改善抑郁症状：太极拳训练能明显改善围绝经期妇女的抑郁症状。太极拳训练改善围绝经期妇女抑郁症状的机制可能是通过调节异常的犬尿氨酸代谢实现的。
期刊介绍：
Experimental Aging Research is a life span developmental and aging journal dealing with research on the aging process from a psychological and psychobiological perspective. It meets the need for a scholarly journal with refereed scientific papers dealing with age differences and age changes at any point in the adult life span. Areas of major focus include experimental psychology, neuropsychology, psychobiology, work research, ergonomics, and behavioral medicine. Original research, book reviews, monographs, and papers covering special topics are published.
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