Functional frontal lobectomy in the surgical treatment of pharmacoresistant frontal lobe epilepsy: how I do it.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-18 DOI:10.1007/s00701-024-06176-x

Francesca Battista, Alice Esposito, Giovanni Muscas, Alessandro Della Puppa

引用次数: 0

Abstract

Background: Frontal lobe epilepsy is pharmacoresistant in 30% of cases, constituting 10-20% of epilepsy surgeries. For cases of no lesional epilepsy (negative MRI), frontal lobectomy is a crucial treatment, historically involving Frontal Anatomical Lobectomy (AFL) with a 33.3% complication risk and 55.7% seizure control.

Methods: We describe Frontal Functional Lobectomy (FFL), in which the boundaries are defined on the patient's functional cortico-subcortical areas, recognized with advanced intraoperative technologies such as tractography and navigated transcranial magnetic stimulation (nTMS).

Conclusions: The FFL allows for a broader resection with a lower rate of postoperative complications than the AFL.

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功能性额叶切除术在药物耐药性额叶癫痫外科治疗中的应用：我是怎么做的。

背景：30%的额叶癫痫具有药物抵抗性，占癫痫手术的10%-20%。对于无病灶癫痫（磁共振成像阴性）病例，额叶切除术是一种重要的治疗方法，历史上额叶解剖切除术（AFL）的并发症风险为33.3%，癫痫发作控制率为55.7%：方法：我们介绍了额叶功能切除术（FFL），该术式根据患者的皮质-皮质下功能区确定边界，并通过先进的术中技术，如束成像和导航经颅磁刺激（nTMS）进行识别：结论：与 AFL 相比，FFL 允许更广泛的切除，术后并发症发生率更低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.