Mucocutaneous Manifestations in Patients with Dengue Fever: From the EPIDENGUE Cohort on Reunion Island.

IF 3.5 4区 医学 Q1 DERMATOLOGY
Olivier Maillard, Clotilde Fera, Elisa Joly, Kevin Diallo, Patrick Mavingui, Yves-Marie Diarra, Yatrika Koumar, André Cabié, Antoine Bertolotti
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Abstract

Nearly 4 billion people live in a dengue risk area worldwide. The prevalence of dengue-related mucocutaneous manifestations and their association with severe dengue differ across studies. The aim of the study was to describe the characteristics of patients with dengue-related mucocutaneous manifestations and to investigate those were associated with severe dengue. A retrospective study was conducted in 2019 among patients with a positive RT-PCR for dengue at the University Hospital of Reunion, which has been experiencing a re-emergence of dengue since 2018. Of 847 patients with confirmed dengue, 283 (33.4%) developed mucocutaneous manifestations. Only manifestations of dehydration such as glossitis, dysgeusia, or conjunctivitis were associated with severe dengue, unlike pruritus and rash, in bivariate analysis but not in multivariate analysis. The rash and pruritus of dengue appear to be accompanied by a pronounced flu-like syndrome in younger people without comorbidity or severity, although careful examination of mucous membranes would better identify signs of dehydration and thus cases likely to worsen.

登革热患者的皮肤黏膜表现:来自留尼汪岛的 EPIDENGUE 群体。
全球有近 40 亿人生活在登革热高危地区。登革热相关粘膜表现的发病率及其与严重登革热的关系在不同研究中存在差异。本研究旨在描述登革热相关皮肤黏膜表现患者的特征,并调查这些特征与严重登革热的相关性。2019年,留尼旺大学医院对登革热RT-PCR检测呈阳性的患者进行了一项回顾性研究。在 847 名确诊登革热患者中,283 人(33.4%)出现了皮肤黏膜表现。在二变量分析中,只有脱水的表现,如舌炎、口腔溃疡或结膜炎与严重登革热有关,而与瘙痒和皮疹不同的是,在多变量分析中,脱水的表现与瘙痒和皮疹无关。登革热的皮疹和瘙痒在年轻人中似乎伴有明显的流感样综合征,但没有合并症或严重程度,不过仔细检查粘膜可以更好地发现脱水迹象,从而发现可能恶化的病例。
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来源期刊
Acta dermato-venereologica
Acta dermato-venereologica 医学-皮肤病学
CiteScore
4.90
自引率
2.80%
发文量
210
审稿时长
6-12 weeks
期刊介绍: Acta Dermato-Venereologica publishes high-quality manuscripts in English in the field of Dermatology and Venereology, dealing with new observations on basic dermatological and venereological research, as well as clinical investigations. Each volume also features a number of Review articles in special areas, as well as short Letters to the Editor to stimulate debate and to disseminate important clinical observations. Acta Dermato-Venereologica has rapid publication times and is amply illustrated with a large number of colour photographs.
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