Point mutation P174L of the penA gene endowing ceftazidime resistance to Burkholderia pseudomallei in China

IF 15.8 1区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Resistance Updates Pub Date : 2024-07-14 DOI:10.1016/j.drup.2024.101121

Shen Tian , Xingyong Wu , Lin Liu , Anyang Li , Xuemiao Li , Hua Pei , Yanshuang Wang , David A.B. Dance , Hai Chen , Qianfeng Xia

引用次数: 0

Abstract

In a clinical isolate of Burkholderia pseudomallei from Hainan, the association between the emergence of ceftazidime resistance and a novel PenA P174L allele was identified for the first time, providing an understanding of one mechanism by which ceftazidime resistance arises in B. pseudomallei.

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中国假丝酵母伯克霍尔德菌对头孢唑肟耐药性的 PenA 基因点突变 P174L

在海南的一个临床分离的假马来伯克霍尔德氏菌中，首次发现了头孢他啶耐药性的出现与新型PenA P174L等位基因之间的关联，从而了解了头孢他啶耐药性在假马来伯克霍尔德氏菌中产生的一种机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Resistance Updates 医学-药学

CiteScore

26.20

自引率

11.90%

发文量

审稿时长

29 days

期刊介绍： Drug Resistance Updates serves as a platform for publishing original research, commentary, and expert reviews on significant advancements in drug resistance related to infectious diseases and cancer. It encompasses diverse disciplines such as molecular biology, biochemistry, cell biology, pharmacology, microbiology, preclinical therapeutics, oncology, and clinical medicine. The journal addresses both basic research and clinical aspects of drug resistance, providing insights into novel drugs and strategies to overcome resistance. Original research articles are welcomed, and review articles are authored by leaders in the field by invitation. Articles are written by leaders in the field, in response to an invitation from the Editors, and are peer-reviewed prior to publication. Articles are clear, readable, and up-to-date, suitable for a multidisciplinary readership and include schematic diagrams and other illustrations conveying the major points of the article. The goal is to highlight recent areas of growth and put them in perspective. *Expert reviews in clinical and basic drug resistance research in oncology and infectious disease *Describes emerging technologies and therapies, particularly those that overcome drug resistance *Emphasises common themes in microbial and cancer research