[Value of calprotectin S100 A8/A9 in predicting the severity of Mycoplasma pneumoniae pneumonia in children].

Q3 Medicine

中国当代儿科杂志 Pub Date : 2024-07-15 DOI:10.7499/j.issn.1008-8830.2401076

Pei Zhou, Li Peng, Lu Xu, Qing-Hua Liu, Han Huang, Li-Li Zhong

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引用次数: 0

Abstract

Objectives: To investigate the role of calprotectin S100 A8/A9 complex in evaluating the condition of children with severe Mycoplasma pneumoniae pneumonia (SMPP).

Methods: A prospective study was conducted among 136 children with Mycoplasma pneumoniae pneumonia (MPP) and 30 healthy controls. According to the severity of the condition, the children with MPP were divided into mild subgroup (40 children) and SMPP subgroup (96 children). The levels of S100 A8/A9 complex and related inflammatory factors were compared between the MPP group and the healthy control group, as well as between the two subgroups of MPP. The role of S100 A8/A9 in assessing the severity of MPP was explored.

Results: The MPP group had a significantly higher level of S100 A8/A9 than the healthy control group, with a significantly greater increase in the SMPP subgroup (P<0.05). The multivariate logistic regression analysis showed that the increases in serum C reactive protein (CRP) and S100A8/A9 were closely associated with SMPP (P<0.05). The receiver operating characteristic (ROC) curve analysis showed that the combined measurement of serum S100 A8/A9 and CRP had an area under the ROC curve of 0.904 in predicting SMPP, which was significantly higher than the AUC of S100 A8/A9 or CRP alone (P<0.05), with a specificity of 0.718 and a sensitivity of 0.952.

Conclusions: S100 A8/A9 is closely associated with the severity of MPP, and the combination of S100 A8/A9 with CRP is more advantageous for assessing the severity of MPP in children.

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[钙蛋白 S100 A8/A9 在预测儿童肺炎支原体肺炎严重程度方面的价值]。

目的研究钙黏蛋白 S100 A8/A9 复合物在评估重症肺炎支原体肺炎（SMPP）患儿病情中的作用：方法：对136名肺炎支原体肺炎（MPP）患儿和30名健康对照者进行了前瞻性研究。根据病情严重程度，MPP患儿被分为轻度亚组（40名）和SMPP亚组（96名）。比较了 MPP 组与健康对照组以及 MPP 两个亚组之间的 S100 A8/A9 复合物和相关炎症因子的水平。探讨了 S100 A8/A9 在评估 MPP 严重程度中的作用：结果：MPP 组的 S100 A8/A9 水平明显高于健康对照组，而在 SMPP 亚组（PPPConclusions：S100 A8/A9与MPP的严重程度密切相关，将S100 A8/A9与CRP结合起来评估儿童MPP的严重程度更有优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国当代儿科杂志 Medicine-Pediatrics, Perinatology and Child Health

CiteScore

1.50

自引率

0.00%

发文量

5006

期刊介绍： The Chinese Journal of Contemporary Pediatrics (CJCP) is a peer-reviewed open access periodical in the field of pediatrics that is sponsored by the Central South University/Xiangya Hospital of Central South University and under the auspices of the Ministry of Education of China. It is cited as a source in the scientific and technological papers of Chinese journals, the Chinese Science Citation Database (CSCD), and is one of the core Chinese periodicals in the Peking University Library. CJCP has been indexed by MEDLINE/PubMed/PMC of the American National Library, American Chemical Abstracts (CA), Holland Medical Abstracts (EM), Western Pacific Region Index Medicus (WPRIM), Scopus and EBSCO. It is a monthly periodical published on the 15th of every month, and is distributed both at home and overseas. The Chinese series publication number is CN 43-1301/R；ISSN 1008-8830. The tenet of CJCP is to “reflect the latest advances and be open to the world”. The periodical reports the most recent advances in the contemporary pediatric field. The majority of the readership is pediatric doctors and researchers.