Lipid Metabolism in Pregnancy Women with Hypothyroidism and Potential Influence on Pregnancy Outcome.

IF 5.9 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Lipids Pub Date : 2024-07-09 eCollection Date: 2024-01-01 DOI:10.1155/2024/5589492
Yuxin Qin, Ying Wu, Huanhuan Zang, Xiangguo Cong, Qiong Shen, Lei Chen, Xinxin Chen
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引用次数: 0

Abstract

Thyroid hormone (TH) is essential for maintaining normal physiological processes during pregnancy, including the metabolism of energy materials in both the mother and fetus and the growth and development of fetal bone and nervous system. TH can act on the liver, fat, and other tissues and organs to participate in lipid synthesis and breakdown through multiple pathways. Consequently, abnormal thyroid function is often accompanied by lipid metabolism disorders. Both clinical and subclinical hypothyroidism, as well as dyslipidemia during pregnancy, have been shown to be associated with an increased risk of multiple adverse pregnancy outcomes. Recently, there has been an increased interest in studying the alteration of lipidomic and hypothyroidism (both clinical and subclinical hypothyroidism) during pregnancy. Studies have suggested that altered lipid molecules might be used as potential biomarker and associated with adverse maternal and neonatal outcome. Thus, we summarized the associations between lipid metabolism and clinical or subclinical hypothyroidism during pregnancy in this review. Then, we discussed the underlying mechanisms of thyroid dysfunction and lipid metabolism. In addition, we reviewed the possible effect of dyslipidemia on pregnancy and neonatal outcome. However, the relationship between hypothyroidism during pregnancy and changes in the lipid profile and how to intervene in the occurrence and development of adverse pregnancy outcomes require further study.

甲状腺功能减退症孕妇的血脂代谢及其对妊娠结果的潜在影响
甲状腺激素(TH)对维持孕期正常生理过程至关重要,包括母亲和胎儿体内能量物质的新陈代谢以及胎儿骨骼和神经系统的生长发育。甲状腺激素可通过多种途径作用于肝脏、脂肪及其他组织和器官,参与脂质的合成和分解。因此,甲状腺功能异常往往伴随着脂质代谢紊乱。临床和亚临床甲状腺功能减退症以及妊娠期血脂异常已被证明与多种不良妊娠结局的风险增加有关。最近,人们对妊娠期脂质体和甲状腺机能减退(包括临床和亚临床甲状腺机能减退)的改变越来越感兴趣。研究表明,脂质分子的改变可作为潜在的生物标志物,并与孕产妇和新生儿的不良结局相关。因此,我们在本综述中总结了脂质代谢与妊娠期临床或亚临床甲减之间的关系。然后,我们讨论了甲状腺功能障碍和脂质代谢的潜在机制。此外,我们还回顾了血脂异常对妊娠和新生儿预后的可能影响。然而,妊娠期甲减与血脂变化之间的关系以及如何干预不良妊娠结局的发生和发展还需要进一步研究。
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来源期刊
Journal of Lipids
Journal of Lipids BIOCHEMISTRY & MOLECULAR BIOLOGY-
自引率
0.00%
发文量
7
审稿时长
12 weeks
期刊介绍: Journal of Lipids is a peer-reviewed, Open Access journal that publishes original research articles and review articles related to all aspects of lipids, including their biochemistry, synthesis, function in health and disease, and nutrition. As an interdisciplinary journal, Journal of Lipids aims to provide a forum for scientists, physicians, nutritionists, and other relevant health professionals.
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