Cuproptosis and Cu: a new paradigm in cellular death and their role in non-cancerous diseases

IF 6.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Apoptosis Pub Date : 2024-07-16 DOI:10.1007/s10495-024-01993-y

Zhibo Yang, Ridong Feng, Hai Zhao

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Abstract

Cuproptosis, a newly characterized form of regulated cell death driven by copper accumulation, has emerged as a significant mechanism underlying various non-cancerous diseases. This review delves into the complex interplay between copper metabolism and the pathogenesis of conditions such as Wilson’s disease (WD), neurodegenerative disorders, and cardiovascular pathologies. We examine the molecular mechanisms by which copper dysregulation induces cuproptosis, highlighting the pivotal roles of key copper transporters and enzymes. Additionally, we evaluate the therapeutic potential of copper chelation strategies, which have shown promise in experimental models by mitigating copper-induced cellular damage and restoring physiological homeostasis. Through a comprehensive synthesis of recent advancements and current knowledge, this review underscores the necessity of further research to translate these findings into clinical applications. The ultimate goal is to harness the therapeutic potential of targeting cuproptosis, thereby improving disease management and patient outcomes in non-cancerous conditions associated with copper dysregulation.

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Cuproptosis和Cu：细胞死亡的新模式及其在非癌症疾病中的作用。

铜中毒（Cuproptosis）是新近发现的一种由铜积累驱动的调节性细胞死亡形式，已成为各种非癌症疾病的重要发病机制。本综述深入探讨了铜代谢与威尔逊氏病（WD）、神经退行性疾病和心血管疾病等发病机制之间复杂的相互作用。我们研究了铜失调诱导铜中毒的分子机制，强调了关键铜转运体和酶的关键作用。此外，我们还评估了铜螯合策略的治疗潜力，这些策略通过减轻铜诱导的细胞损伤和恢复生理平衡，在实验模型中显示出了良好的前景。通过对最新进展和现有知识的全面综述，本综述强调了进一步研究将这些发现转化为临床应用的必要性。我们的最终目标是利用针对铜氧化酶的治疗潜力，从而改善与铜失调相关的非癌症患者的疾病管理和治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Apoptosis 生物-生化与分子生物学

CiteScore

9.10

自引率

4.20%

发文量

审稿时长

1 months

期刊介绍： Apoptosis, a monthly international peer-reviewed journal, focuses on the rapid publication of innovative investigations into programmed cell death. The journal aims to stimulate research on the mechanisms and role of apoptosis in various human diseases, such as cancer, autoimmune disease, viral infection, AIDS, cardiovascular disease, neurodegenerative disorders, osteoporosis, and aging. The Editor-In-Chief acknowledges the importance of advancing clinical therapies for apoptosis-related diseases. Apoptosis considers Original Articles, Reviews, Short Communications, Letters to the Editor, and Book Reviews for publication.