Optimization of Zwitterionic Polymers for Cell Cryopreservation

IF 4.4 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Macromolecular bioscience Pub Date : 2024-07-15 DOI:10.1002/mabi.202470016

Yui Kato, Takuya Uto, Takeru Ishizaki, Daisuke Tanaka, Kojiro Ishibashi, Yuya Matsuda, Issei Onoda, Akiko Kobayashi, Masaharu Hazawa, Richard W. Wong, Kenji Takahashi, Eishu Hirata, Kosuke Kuroda

引用次数: 0

Abstract

Front Cover: In article 2300499, Kosuke Kuroda and co-workers optimize an isotonic freezing medium composed of poly(zwitterion), which alleviates osmotic shock unlike typical hypertonic freezing media. Imidazolium/carboxylate-type poly(zwitterion) is the optimal chemical structure. This illustration shows that the optimized poly(zwitterion) protects cells from ice crystal formation by forming a matrix around the cell membrane.

Abstract Image

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优化用于细胞冷冻保存的聚合离子聚合物

封面：在第 2300499 号文章中，Kosuke Kuroda 及其合作者优化了一种由聚(齐聚物)组成的等渗冷冻培养基，与典型的高渗冷冻培养基不同，这种培养基可减轻渗透休克。咪唑/羧酸盐型聚(齐聚物)是最佳化学结构。图中显示，优化后的聚齐特离子可在细胞膜周围形成基质，从而保护细胞免受冰晶形成的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Macromolecular bioscience 生物-材料科学：生物材料

CiteScore

7.90

自引率

2.20%

发文量

211

审稿时长

1.5 months

期刊介绍： Macromolecular Bioscience is a leading journal at the intersection of polymer and materials sciences with life science and medicine. With an Impact Factor of 2.895 (2018 Journal Impact Factor, Journal Citation Reports (Clarivate Analytics, 2019)), it is currently ranked among the top biomaterials and polymer journals. Macromolecular Bioscience offers an attractive mixture of high-quality Reviews, Feature Articles, Communications, and Full Papers. With average reviewing times below 30 days, publication times of 2.5 months and listing in all major indices, including Medline, Macromolecular Bioscience is the journal of choice for your best contributions at the intersection of polymer and life sciences.