Spontaneous conception in a 40-year-old woman after allogeneic stem cell transplant with active graft-versus-host disease: A case report

IF 0.7 Q4 OBSTETRICS & GYNECOLOGY

Case Reports in Women's Health Pub Date : 2024-07-09 DOI:10.1016/j.crwh.2024.e00636

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Abstract

This article presents a case of spontaneous conception and live birth in a 40-year-old woman who had undergone gonadotoxic chemotherapy and allogenic stem cell transplant for relapsed acute myelogenous leukemia complicated by treatment-refractory graft-versus-host disease. The patient's follicle stimulating hormone level was 44.4 mIU/mL at age 38 and then decreased to 4.1 mIU/mL at age 41, suggesting ovarian recovery. Her graft-versus-host disease subjectively improved during pregnancy. She ultimately delivered a healthy neonate. This case demonstrates the potential for ovarian recovery after stem allogenic cell transplant in a patient of advanced reproductive age and provides insight into the limited knowledge about graft-versus-host disease in pregnancy. As survival after stem cell transplant continues to improve, understanding the downstream consequences of the treatment, including for fertility and pregnancy, is of growing importance.

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一名 40 岁女性在异体干细胞移植后自然受孕，并伴有活动性移植物抗宿主病：病例报告

本文介绍了一例自然受孕和活产的病例，患者是一名40岁女性，曾因复发的急性髓性白血病并发治疗难治性移植物抗宿主病而接受性腺毒性化疗和异基因干细胞移植。患者38岁时的促卵泡激素水平为44.4 mIU/mL，41岁时降至4.1 mIU/mL，表明卵巢已恢复。在怀孕期间，她的移植物抗宿主疾病得到了主观改善。她最终产下了一个健康的新生儿。本病例表明，高龄育龄患者在进行异基因干细胞移植后，卵巢有可能恢复，并让我们了解到有关妊娠期移植物抗宿主疾病的有限知识。随着干细胞移植后存活率的不断提高，了解治疗的下游后果，包括对生育和怀孕的影响，变得越来越重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Case Reports in Women's Health Medicine-Obstetrics and Gynecology

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

7 days