A concise and mild condition for Pd-catalyzed C(sp2)–H arylation

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2024-07-11 DOI:10.1016/j.tetlet.2024.155195

引用次数: 0

Abstract

It is particularly significant to develop mild and efficient methods to construct 2-aryl-substituted benzoic acids framwork due to their wide existence in many important natural organic compounds. Here, we report a concise and mild method to synthesize ortho-arylation of benzoic acids. In this mild catalytic system, decarboxylation byproducts were not observed. Meanwhile, the high yields could be obtained in the absence of ligands.

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钯催化 C（sp2）-H 芳基化的简明温和条件

由于 2-芳基取代的苯甲酸广泛存在于许多重要的天然有机化合物中，因此开发温和高效的方法来构建 2-芳基取代的苯甲酸框架尤为重要。在此，我们报告了一种合成苯甲酸正芳基化的简便而温和的方法。在这种温和的催化体系中，没有观察到脱羧副产物。同时，在没有配体的情况下也能获得高产率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.